6bqp: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,332,843 edits
m Protected "6bqp" [edit=sysop:move=sysop]
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,332,843 edits
No edit summary
 
(2 intermediate revisions by the same user not shown)
Line 1: Line 1:
'''Unreleased structure'''


The entry 6bqp is ON HOLD
==Crystal Structure of the Human CAMKK2B in complex with Crenolanib==
<StructureSection load='6bqp' size='340' side='right'caption='[[6bqp]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6bqp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BQP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BQP FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6T2:1-(2-{5-[(3-Methyloxetan-3-yl)methoxy]-1H-benzimidazol-1-yl}quinolin-8-yl)piperidin-4-amine'>6T2</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bqp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bqp OCA], [https://pdbe.org/6bqp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bqp RCSB], [https://www.ebi.ac.uk/pdbsum/6bqp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bqp ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KKCC2_HUMAN KKCC2_HUMAN] Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.<ref>PMID:11395482</ref> <ref>PMID:12935886</ref> <ref>PMID:9662074</ref> <ref>PMID:21957496</ref>


Authors: Counago, R.M., de Souza, G.P., dos Reis, C.V., Ramos, P.Z., Drewry, D., Massirer, K.B., Arruda, P., Edwards, A.M., Elkins, J.M., Structural Genomics Consortium (SGC)
==See Also==
 
*[[Calcium/calmodulin-dependent protein kinase kinase|Calcium/calmodulin-dependent protein kinase kinase]]
Description: Crystal Structure of the Human CAMKK2B in complex with Crenolanib
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Elkins, J.M]]
__TOC__
[[Category: Drewry, D]]
</StructureSection>
[[Category: Edwards, A.M]]
[[Category: Homo sapiens]]
[[Category: Arruda, P]]
[[Category: Large Structures]]
[[Category: Structural Genomics Consortium (Sgc)]]
[[Category: Arruda P]]
[[Category: Massirer, K.B]]
[[Category: Counago RM]]
[[Category: Ramos, P.Z]]
[[Category: Drewry D]]
[[Category: Counago, R.M]]
[[Category: Edwards AM]]
[[Category: Dos Reis, C.V]]
[[Category: Elkins JM]]
[[Category: De Souza, G.P]]
[[Category: Massirer KB]]
[[Category: Ramos PZ]]
[[Category: De Souza GP]]
[[Category: Dos Reis CV]]
Retrieved from "https://proteopedia.org/6bqp"