6of0: Difference between revisions

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<StructureSection load='6of0' size='340' side='right'caption='[[6of0]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='6of0' size='340' side='right'caption='[[6of0]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6of0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"diplococcus_gonorrhoeae"_(zopf_1885)_lehmann_and_neumann_1896 "diplococcus gonorrhoeae" (zopf 1885) lehmann and neumann 1896]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OF0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OF0 FirstGlance]. <br>
<table><tr><td colspan='2'>[[6of0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Neisseria_gonorrhoeae Neisseria gonorrhoeae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OF0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6OF0 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3vib|3vib]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">mtrR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=485 "Diplococcus gonorrhoeae" (Zopf 1885) Lehmann and Neumann 1896])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6of0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6of0 OCA], [https://pdbe.org/6of0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6of0 RCSB], [https://www.ebi.ac.uk/pdbsum/6of0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6of0 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6of0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6of0 OCA], [http://pdbe.org/6of0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6of0 RCSB], [http://www.ebi.ac.uk/pdbsum/6of0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6of0 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/MTRR_NEIGO MTRR_NEIGO]] Controls the permeability of the cell envelope to hydrophobic compounds such as antibiotics and detergents (PubMed:8196548). Represses transcription of the mtrCDE-encoded efflux pump by binding within the mtrCDE promoter (PubMed:9209024, PubMed:23221802). Also negatively regulates the expression of farR, by binding to its promoter region, leading indirectly to the positive regulation of expression of the farAB-encoded efflux pump (PubMed:14645274).<ref>PMID:14645274</ref> <ref>PMID:23221802</ref> <ref>PMID:8196548</ref> <ref>PMID:9209024</ref>
[https://www.uniprot.org/uniprot/MTRR_NEIGO MTRR_NEIGO] Controls the permeability of the cell envelope to hydrophobic compounds such as antibiotics and detergents (PubMed:8196548). Represses transcription of the mtrCDE-encoded efflux pump by binding within the mtrCDE promoter (PubMed:9209024, PubMed:23221802). Also negatively regulates the expression of farR, by binding to its promoter region, leading indirectly to the positive regulation of expression of the farAB-encoded efflux pump (PubMed:14645274).<ref>PMID:14645274</ref> <ref>PMID:23221802</ref> <ref>PMID:8196548</ref> <ref>PMID:9209024</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6of0" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6of0" style="background-color:#fffaf0;"></div>
==See Also==
*[[Tetracycline repressor protein 3D structures|Tetracycline repressor protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Beggs, G A]]
[[Category: Neisseria gonorrhoeae]]
[[Category: Brennan, R G]]
[[Category: Beggs GA]]
[[Category: Kumaraswami, M]]
[[Category: Brennan RG]]
[[Category: Shafer, W]]
[[Category: Kumaraswami M]]
[[Category: Dna binding protein]]
[[Category: Shafer W]]
[[Category: Tetr family]]
[[Category: Transcription regulator]]
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