6wan: Difference between revisions
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<StructureSection load='6wan' size='340' side='right'caption='[[6wan]], [[Resolution|resolution]] 2.40Å' scene=''> | <StructureSection load='6wan' size='340' side='right'caption='[[6wan]], [[Resolution|resolution]] 2.40Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6wan]] is a 12 chain structure with sequence from [ | <table><tr><td colspan='2'>[[6wan]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_baumannii Acinetobacter baumannii] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WAN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WAN FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wan FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wan OCA], [https://pdbe.org/6wan PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wan RCSB], [https://www.ebi.ac.uk/pdbsum/6wan PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wan ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/CAP4_ACIS2 CAP4_ACIS2] CBASS (cyclic oligonucleotide-based antiphage signaling system) provides immunity against bacteriophage. The CD-NTase protein synthesizes cyclic nucleotides in response to infection; these serve as specific second messenger signals. The signals activate a diverse range of effectors, leading to bacterial cell death and thus abortive phage infection. A type II-C(AAAA) CBASS system (PubMed:32839535).<ref>PMID:32839535</ref> <ref>PMID:32544385</ref> Binds cyclic nucleotide second messengers (synthesized by CdnD, the cognate CD-NTase in the CBASS operon). Ligand binding activates it to endonucleolytically degrade dsDNA to approximately 6 bp length fragments, with a preference for 5'-C or 5'-G cleavage site. The minor product of CdnD is the activating nucleotide; also binds the major product (2',3',3'-cyclic AMP-AMP-AMP) but is not activated by it. Only binds DNA in the presence of ligand. Is not activated by c-di-AMP, c-di-GMP, 3'3'-cyclic GMP-AMP (3'3'-cGAMP) or 3',3',3'-cyclic AMP-AMP-GMP.<ref>PMID:32544385</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Acinetobacter baumannii]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Antine | [[Category: Synthetic construct]] | ||
[[Category: Cabrera | [[Category: Antine SP]] | ||
[[Category: Keszei | [[Category: Cabrera V]] | ||
[[Category: Kranzusch | [[Category: Keszei AFA]] | ||
[[Category: Lee | [[Category: Kranzusch PJ]] | ||
[[Category: Lowey | [[Category: Lee ASY]] | ||
[[Category: Mekalanos | [[Category: Lowey B]] | ||
[[Category: Morehouse | [[Category: Mekalanos JJ]] | ||
[[Category: Schwede | [[Category: Morehouse BR]] | ||
[[Category: Shao | [[Category: Schwede F]] | ||
[[Category: Whiteley | [[Category: Shao S]] | ||
[[Category: Whiteley AT]] | |||
