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==Crystal structure of the thermostable Japanese firefly Luciferase complexed with OXYLUCIFERIN and AMP==
==Crystal structure of the thermostable Japanese firefly Luciferase complexed with OXYLUCIFERIN and AMP==
<StructureSection load='2d1r' size='340' side='right' caption='[[2d1r]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
<StructureSection load='2d1r' size='340' side='right'caption='[[2d1r]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2d1r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Luciola_cruciata Luciola cruciata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D1R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2D1R FirstGlance]. <br>
<table><tr><td colspan='2'>[[2d1r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Luciola_cruciata Luciola cruciata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D1R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2D1R FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=OLU:2-(6-HYDROXY-1,3-BENZOTHIAZOL-2-YL)-1,3-THIAZOL-4(5H)-ONE'>OLU</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=OLU:2-(6-HYDROXY-1,3-BENZOTHIAZOL-2-YL)-1,3-THIAZOL-4(5H)-ONE'>OLU</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2d1s|2d1s]], [[2d1t|2d1t]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d1r OCA], [https://pdbe.org/2d1r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d1r RCSB], [https://www.ebi.ac.uk/pdbsum/2d1r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d1r ProSAT], [https://www.topsan.org/Proteins/RSGI/2d1r TOPSAN]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Photinus-luciferin_4-monooxygenase_(ATP-hydrolyzing) Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.12.7 1.13.12.7] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2d1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d1r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2d1r RCSB], [http://www.ebi.ac.uk/pdbsum/2d1r PDBsum], [http://www.topsan.org/Proteins/RSGI/2d1r TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/LUCI_LUCCR LUCI_LUCCR]] Produces green light with a wavelength of 544 nm.  
[https://www.uniprot.org/uniprot/LUCI_LUCCR LUCI_LUCCR] Produces green light with a wavelength of 544 nm.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d1/2d1r_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d1/2d1r_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2d1r ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 2d1r" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Luciferase|Luciferase]]
*[[Luciferase 3D structures|Luciferase 3D structures]]
*[[Luciola cruciata luciferase|Luciola cruciata luciferase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Luciola cruciata]]
[[Category: Luciola cruciata]]
[[Category: Hiratake, J]]
[[Category: Hiratake J]]
[[Category: Ichiyama, S]]
[[Category: Ichiyama S]]
[[Category: Kato, H]]
[[Category: Kato H]]
[[Category: Kobashi, N]]
[[Category: Kobashi N]]
[[Category: Nakatsu, T]]
[[Category: Nakatsu T]]
[[Category: Structural genomic]]
[[Category: Sakata K]]
[[Category: Sakata, K]]
[[Category: Saldanha A]]
[[Category: Saldanha, A]]
[[Category: Alpha+beta]]
[[Category: Alpha/beta]]
[[Category: Beta barrel]]
[[Category: Oxidoreductase]]
[[Category: Rsgi]]