2d5b: Difference between revisions

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[[Image:2d5b.jpg|left|200px]]<br /><applet load="2d5b" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2d5b, resolution 1.8&Aring;" />
'''Crystal Structure of Thermus Thermophilus Methionyl tRNA synthetase Y225F Mutant obtained in the presence of PEG6000'''<br />


==About this Structure==
==Crystal Structure of Thermus Thermophilus Methionyl tRNA synthetase Y225F Mutant obtained in the presence of PEG6000==
2D5B is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Methionine--tRNA_ligase Methionine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.10 6.1.1.10] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D5B OCA].  
<StructureSection load='2d5b' size='340' side='right'caption='[[2d5b]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
[[Category: Methionine--tRNA ligase]]
== Structural highlights ==
[[Category: Single protein]]
<table><tr><td colspan='2'>[[2d5b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D5B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2D5B FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d5b OCA], [https://pdbe.org/2d5b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d5b RCSB], [https://www.ebi.ac.uk/pdbsum/2d5b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d5b ProSAT], [https://www.topsan.org/Proteins/RSGI/2d5b TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SYM_THET8 SYM_THET8] Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d5/2d5b_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2d5b ConSurf].
<div style="clear:both"></div>
 
==See Also==
*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Thermus thermophilus]]
[[Category: Thermus thermophilus]]
[[Category: Ishii, R.]]
[[Category: Ishii R]]
[[Category: Konno, M.]]
[[Category: Konno M]]
[[Category: Mori, Y.]]
[[Category: Mori Y]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Takasaka R]]
[[Category: Takasaka, R.]]
[[Category: Takeda R]]
[[Category: Takeda, R.]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S.]]
[[Category: ZN]]
[[Category: class 1a aars]]
[[Category: isomerase]]
[[Category: national project on protein structural and functional analyses]]
[[Category: nppsfa]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rossmann fold]]
[[Category: rsgi]]
[[Category: structural genomics]]
 
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Retrieved from "https://proteopedia.org/2d5b"