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[[Image:2dxt.jpg|left|200px]]


{{Structure
==Crystal Structure Of Biotin Protein Ligase From Pyrococcus Horikoshii Complexed with ATP and Biotin, Mutation D104A==
|PDB= 2dxt |SIZE=350|CAPTION= <scene name='initialview01'>2dxt</scene>, resolution 1.60&Aring;
<StructureSection load='2dxt' size='340' side='right'caption='[[2dxt]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=ATP:ADENOSINE-5'-TRIPHOSPHATE'>ATP</scene> and <scene name='pdbligand=BTN:BIOTIN'>BTN</scene>
<table><tr><td colspan='2'>[[2dxt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DXT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DXT FirstGlance]. <br>
|ACTIVITY= [http://en.wikipedia.org/wiki/Biotin--[acetyl-CoA-carboxylase]_ligase Biotin--[acetyl-CoA-carboxylase] ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.15 6.3.4.15]  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
|GENE= birA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=53953 Pyrococcus horikoshii])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=BTN:BIOTIN'>BTN</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dxt OCA], [https://pdbe.org/2dxt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dxt RCSB], [https://www.ebi.ac.uk/pdbsum/2dxt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dxt ProSAT], [https://www.topsan.org/Proteins/RSGI/2dxt TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/O57883_PYRHO O57883_PYRHO]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dx/2dxt_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dxt ConSurf].
<div style="clear:both"></div>


'''Crystal Structure Of Biotin Protein Ligase From Pyrococcus Horikoshii Complexed with ATP and Biotin, Mutation D104A'''
==See Also==
 
*[[Biotin Protein Ligase 3D structures|Biotin Protein Ligase 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
2DXT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DXT OCA].
[[Category: Large Structures]]
[[Category: Biotin--[acetyl-CoA-carboxylase] ligase]]
[[Category: Pyrococcus horikoshii]]
[[Category: Pyrococcus horikoshii]]
[[Category: Single protein]]
[[Category: Bagautdinov B]]
[[Category: Bagautdinov, B.]]
[[Category: Kunishima N]]
[[Category: Kunishima, N.]]
[[Category: Matsuura Y]]
[[Category: Matsuura, Y.]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: ATP]]
[[Category: BTN]]
[[Category: biotin biosynthesis]]
[[Category: dimer]]
[[Category: national project on protein structural and functional analyse]]
[[Category: nppsfa]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rsgi]]
[[Category: structural genomic]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:32:55 2008''
Retrieved from "https://proteopedia.org/2dxt"