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[[Image:2dzb.gif|left|200px]]


{{Structure
==Crystal Structure of Dihydropteroate Synthase from Thermus thermophilus HB8 in complex with 6HMPPP==
|PDB= 2dzb |SIZE=350|CAPTION= <scene name='initialview01'>2dzb</scene>, resolution 1.90&Aring;
<StructureSection load='2dzb' size='340' side='right'caption='[[2dzb]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=HH2:6-HYDROXYMETHYLPTERIN-DIPHOSPHATE'>HH2</scene>
<table><tr><td colspan='2'>[[2dzb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DZB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DZB FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydropteroate_synthase Dihydropteroate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.15 2.5.1.15] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
|GENE= FolP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 Thermus thermophilus])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HH2:6-HYDROXYMETHYLPTERIN-DIPHOSPHATE'>HH2</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dzb OCA], [https://pdbe.org/2dzb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dzb RCSB], [https://www.ebi.ac.uk/pdbsum/2dzb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dzb ProSAT], [https://www.topsan.org/Proteins/RSGI/2dzb TOPSAN]</span></td></tr>
|RELATEDENTRY=[[2dqw|2DQW]], [[2dza|2DZA]]
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dzb OCA], [http://www.ebi.ac.uk/pdbsum/2dzb PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2dzb RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/Q5SLV2_THET8 Q5SLV2_THET8] DHPS catalyzes the formation of the immediate precursor of folic acid.[RuleBase:RU361205]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dz/2dzb_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dzb ConSurf].
<div style="clear:both"></div>


'''Crystal Structure of Dihydropteroate Synthase from Thermus thermophilus HB8 in complex with 6HMPPP'''
==See Also==
 
*[[Dihydropteroate synthase 3D structures|Dihydropteroate synthase 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
2DZB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DZB OCA].
[[Category: Large Structures]]
[[Category: Dihydropteroate synthase]]
[[Category: Single protein]]
[[Category: Thermus thermophilus]]
[[Category: Thermus thermophilus]]
[[Category: Bagautdinov, B.]]
[[Category: Bagautdinov B]]
[[Category: Kunishima, N.]]
[[Category: Kunishima N]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: 6hmppp]]
[[Category: dihydropteroate synthase]]
[[Category: dimer]]
[[Category: national project on protein structural and functional analyse]]
[[Category: nppsfa]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rsgi]]
[[Category: structural genomic]]
[[Category: x-ray diffraction]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:41:31 2008''

Latest revision as of 08:32, 25 October 2023

Crystal Structure of Dihydropteroate Synthase from Thermus thermophilus HB8 in complex with 6HMPPP

2dzb, resolution 1.90Å

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