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[[Image:2e5x.gif|left|200px]]


{{Structure
==Structure of nucleotide triphosphate pyrophosphatase from pyrococcus horikoshii OT3==
|PDB= 2e5x |SIZE=350|CAPTION= <scene name='initialview01'>2e5x</scene>, resolution 2.00&Aring;
<StructureSection load='2e5x' size='340' side='right'caption='[[2e5x]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ITT:INOSINE+5&#39;-TRIPHOSPHATE'>ITT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>
<table><tr><td colspan='2'>[[2e5x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii_OT3 Pyrococcus horikoshii OT3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E5X FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Nucleoside-triphosphate_diphosphatase Nucleoside-triphosphate diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.19 3.6.1.19] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
|GENE=
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ITT:INOSINE+5-TRIPHOSPHATE'>ITT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e5x OCA], [https://pdbe.org/2e5x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e5x RCSB], [https://www.ebi.ac.uk/pdbsum/2e5x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e5x ProSAT], [https://www.topsan.org/Proteins/RSGI/2e5x TOPSAN]</span></td></tr>
|RELATEDENTRY=
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e5x OCA], [http://www.ebi.ac.uk/pdbsum/2e5x PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2e5x RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/IXTPA_PYRHO IXTPA_PYRHO] Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.[HAMAP-Rule:MF_01405]<ref>PMID:18062990</ref>
 
== Evolutionary Conservation ==
'''Structure of nucleotide triphosphate pyrophosphatase from pyrococcus horikoshii OT3'''
[[Image:Consurf_key_small.gif|200px|right]]
 
Check<jmol>
 
  <jmolCheckbox>
==About this Structure==
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e5/2e5x_consurf.spt"</scriptWhenChecked>
2E5X is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5X OCA].  
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: Nucleoside-triphosphate diphosphatase]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: Pyrococcus horikoshii]]
  </jmolCheckbox>
[[Category: Single protein]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e5x ConSurf].
[[Category: Kunishima, N.]]
<div style="clear:both"></div>
[[Category: Lokanath, N K.]]
== References ==
[[Category: Mizutani, H.]]
<references/>
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
__TOC__
[[Category: national project on protein structural and functional analyse]]
</StructureSection>
[[Category: nppsfa]]
[[Category: Large Structures]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: Pyrococcus horikoshii OT3]]
[[Category: rsgi]]
[[Category: Kunishima N]]
[[Category: structural genomic]]
[[Category: Lokanath NK]]
 
[[Category: Mizutani H]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:44:12 2008''

Latest revision as of 08:35, 25 October 2023

Structure of nucleotide triphosphate pyrophosphatase from pyrococcus horikoshii OT3

2e5x, resolution 2.00Å

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