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==Crystal Structure of the Kif1A Motor Domain Before Mg Release==
==Crystal Structure of the Kif1A Motor Domain Before Mg Release==
<StructureSection load='2zfi' size='340' side='right' caption='[[2zfi]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
<StructureSection load='2zfi' size='340' side='right'caption='[[2zfi]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2zfi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZFI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZFI FirstGlance]. <br>
<table><tr><td colspan='2'>[[2zfi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZFI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZFI FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1vfv|1vfv]], [[1vfw|1vfw]], [[1vfx|1vfx]], [[1vfz|1vfz]], [[1i6i|1i6i]], [[1i5s|1i5s]], [[2zfj|2zfj]], [[2zfk|2zfk]], [[2zfl|2zfl]], [[2zfm|2zfm]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zfi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zfi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zfi RCSB], [http://www.ebi.ac.uk/pdbsum/2zfi PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zfi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zfi OCA], [https://pdbe.org/2zfi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zfi RCSB], [https://www.ebi.ac.uk/pdbsum/2zfi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zfi ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/KIF1A_MOUSE KIF1A_MOUSE]] Motor for anterograde axonal transport of synaptic vesicle precursors.  
[https://www.uniprot.org/uniprot/KIF1A_MOUSE KIF1A_MOUSE] Motor for anterograde axonal transport of synaptic vesicle precursors.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zf/2zfi_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zf/2zfi_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zfi ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 2zfi" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Kinesin|Kinesin]]
*[[Kinesin|Kinesin]]
*[[Kinesin 3D Structures|Kinesin 3D Structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Hirokawa, N]]
[[Category: Hirokawa N]]
[[Category: Nitta, R]]
[[Category: Nitta R]]
[[Category: Okada, Y]]
[[Category: Okada Y]]
[[Category: Alpha and beta protein]]
[[Category: Atp-binding]]
[[Category: Atpase]]
[[Category: Enzyme]]
[[Category: Kinesin]]
[[Category: Microtubule]]
[[Category: Motor protein]]
[[Category: Nucleotide-binding]]
[[Category: P-loop]]
[[Category: Transport protein]]

Latest revision as of 13:35, 1 November 2023

Crystal Structure of the Kif1A Motor Domain Before Mg Release

2zfi, resolution 1.55Å

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