3dab: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
 
(10 intermediate revisions by the same user not shown)
Line 1: Line 1:
{{Seed}}
[[Image:3dab.jpg|left|200px]]


<!--
==Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain==
The line below this paragraph, containing "STRUCTURE_3dab", creates the "Structure Box" on the page.
<StructureSection load='3dab' size='340' side='right'caption='[[3dab]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3dab]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DAB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DAB FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dab FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dab OCA], [https://pdbe.org/3dab PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dab RCSB], [https://www.ebi.ac.uk/pdbsum/3dab PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dab ProSAT]</span></td></tr>
{{STRUCTURE_3dab|  PDB=3dab  |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/MDM4_HUMAN MDM4_HUMAN] Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.<ref>PMID:16163388</ref> <ref>PMID:16511572</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/da/3dab_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dab ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The Mdmx oncoprotein has only recently emerged as a critical-independent to Mdm2-regulator of p53 activation. We have determined the crystal structure of the N-terminal domain of human Mdmx bound to a 15-residue transactivation domain peptide of human p53. The structure shows why antagonists of the Mdm2 binding to p53 are ineffective in the Mdmx-p53 interaction.


===Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain===
Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain.,Popowicz GM, Czarna A, Holak TA Cell Cycle. 2008 Aug;7(15):2441-3. Epub 2008 May 27. PMID:18677113<ref>PMID:18677113</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3dab" style="background-color:#fffaf0;"></div>


<!--
==See Also==
The line below this paragraph, {{ABSTRACT_PUBMED_18677113}}, adds the Publication Abstract to the page
*[[MDM4|MDM4]]
(as it appears on PubMed at http://www.pubmed.gov), where 18677113 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_18677113}}
__TOC__
 
</StructureSection>
==About this Structure==
3DAB is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DAB OCA].
 
==Reference==
Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain., Popowicz GM, Czarna A, Holak TA, Cell Cycle. 2008 Aug;7(15):2441-3. Epub 2008 May 27. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18677113 18677113]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Large Structures]]
[[Category: Czarna, A.]]
[[Category: Czarna A]]
[[Category: Holak, T A.]]
[[Category: Holak TA]]
[[Category: Popowicz, G M.]]
[[Category: Popowicz GM]]
[[Category: Apoptosis]]
[[Category: Cell cycle]]
[[Category: Disease mutation]]
[[Category: Dna-binding]]
[[Category: Hdm2]]
[[Category: Hdm4]]
[[Category: Hdmx]]
[[Category: Mdm-4]]
[[Category: Mdm-x]]
[[Category: Mdm2]]
[[Category: Mdm4]]
[[Category: Mdmx]]
[[Category: Nucleus]]
[[Category: Oncogene]]
[[Category: P53]]
[[Category: Transcription]]
[[Category: Tumor]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep  3 13:13:11 2008''
Retrieved from "https://proteopedia.org/3dab"