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==Crystal structure of F47Y variant of TenA (HP1287) from Helicobacter pylori==
==Crystal structure of F47Y variant of TenA (HP1287) from Helicobacter pylori==
<StructureSection load='3ibx' size='340' side='right' caption='[[3ibx]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='3ibx' size='340' side='right'caption='[[3ibx]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3ibx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43504 Atcc 43504]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IBX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IBX FirstGlance]. <br>
<table><tr><td colspan='2'>[[3ibx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IBX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IBX FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2rd3|2rd3]], [[1to9|1to9]], [[1tyh|1tyh]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">tenA, HP1287 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=210 ATCC 43504])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ibx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ibx OCA], [https://pdbe.org/3ibx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ibx RCSB], [https://www.ebi.ac.uk/pdbsum/3ibx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ibx ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aminopyrimidine_aminohydrolase Aminopyrimidine aminohydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.99.2 3.5.99.2] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ibx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ibx OCA], [http://pdbe.org/3ibx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ibx RCSB], [http://www.ebi.ac.uk/pdbsum/3ibx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ibx ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TENA_HELPX TENA_HELPX] Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds to give a hydroxymethylpyrimidine (HMP). Displays low activity on 4-amino-5-aminomethyl-2-methylpyrimidine as substrate, indicating that the enzyme may act on a different HMP precursor that may derive from the human stomach food assumption or processing. Is probably involved in thiamine biosynthesis. Does not display thiaminase II activity, as it is unable to hydrolyze thiamine.<ref>PMID:19780837</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Aminopyrimidine aminohydrolase]]
[[Category: Atcc 43504]]
[[Category: Angelini, A]]
[[Category: Barison, N]]
[[Category: Cendron, L]]
[[Category: Trento, A]]
[[Category: Zanotti, G]]
[[Category: Helicobacter pylori]]
[[Category: Helicobacter pylori]]
[[Category: Hydrolase]]
[[Category: Large Structures]]
[[Category: Thiamin]]
[[Category: Angelini A]]
[[Category: Thiaminase]]
[[Category: Barison N]]
[[Category: Vitamin b1]]
[[Category: Cendron L]]
[[Category: Trento A]]
[[Category: Zanotti G]]
Retrieved from "https://proteopedia.org/3ibx"