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{{STRUCTURE_3nug|  PDB=3nug  |  SCENE=  }}
===Crystal structure of wild type tetrameric pyridoxal 4-dehydrogenase from Mesorhizobium loti===
{{ABSTRACT_PUBMED_21307574}}


==About this Structure==
==Crystal structure of wild type tetrameric pyridoxal 4-dehydrogenase from Mesorhizobium loti==
[[3nug]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mesorhizobium_loti Mesorhizobium loti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NUG OCA].  
<StructureSection load='3nug' size='340' side='right'caption='[[3nug]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3nug]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mesorhizobium_loti Mesorhizobium loti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NUG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NUG FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.788&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nug OCA], [https://pdbe.org/3nug PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nug RCSB], [https://www.ebi.ac.uk/pdbsum/3nug PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nug ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PLDH_RHILO PLDH_RHILO] Involved in the degradation of pyridoxine or pyridoxamine (free, phosphate-unbound, forms of vitamin B6). Oxidizes pyridoxal to 4-pyridoxolactone, but does not have activity toward pyridoxal 5'-phosphate, pyridoxine, pyridoxamine, pyridoxamine 5'-phosphate, 4-phthalaldehyde, 2-nitrobenzaldehyde, pyridine, formaldehyde, 2-carboxybenzaldehyde or sugars.<ref>PMID:16824480</ref>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Pyridoxal 4-dehydrogenase catalyzes the irreversible oxidation of pyridoxal to 4-pyridoxolactone and is involved in degradation pathway I of pyridoxine, a vitamin B(6) compound. Its crystal structure was elucidated for the first time. Molecular replacement with (S)-1-phenylthanol dehydrogenase (PDB code 2EW8) was adopted to determine the tertiary structure of the NAD(+)-bound enzyme.


==Reference==
The crystal structure of SDR-type pyridoxal 4-dehydrogenase of Mesorhizobium loti.,Chu HN, Kobayashi J, Mikami B, Yagi T Biosci Biotechnol Biochem. 2011;75(2):388-90. Epub 2011 Feb 7. PMID:21307574<ref>PMID:21307574</ref>
<ref group="xtra">PMID:021307574</ref><ref group="xtra">PMID:020516609</ref><references group="xtra"/><references/>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3nug" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mesorhizobium loti]]
[[Category: Mesorhizobium loti]]
[[Category: Pyridoxal 4-dehydrogenase]]
[[Category: Chu HN]]
[[Category: Chu, H N.]]
[[Category: 4-pyridoxolactone]]
[[Category: Oxidoreductase]]
[[Category: Pyridoxal]]
[[Category: Short chain dehydrogenase/reductase]]
[[Category: Tpldh]]
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