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==Crystal structure of tetrahydrocannabinolic acid synthase from Cannabis sativa==
==Crystal structure of tetrahydrocannabinolic acid synthase from Cannabis sativa==
<StructureSection load='3vte' size='340' side='right' caption='[[3vte]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
<StructureSection load='3vte' size='340' side='right'caption='[[3vte]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3vte]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cansa Cansa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VTE OCA]. <br>
<table><tr><td colspan='2'>[[3vte]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cannabis_sativa Cannabis sativa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VTE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VTE FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vte FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vte OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vte RCSB], [http://www.ebi.ac.uk/pdbsum/3vte PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vte FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vte OCA], [https://pdbe.org/3vte PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vte RCSB], [https://www.ebi.ac.uk/pdbsum/3vte PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vte ProSAT]</span></td></tr>
<table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/THCAS_CANSA THCAS_CANSA] Catalyzes the oxidative cyclization of the monoterpene moiety in cannabigerolic acid (CBGA), producing delta(9)-tetrahydrocannabinolate (THCA), the major cannabioid in drug-type Cannabis plants. Can also use cannabinerolic acid as substrate, but not cannabigerol or cannabinerol.<ref>PMID:15190053</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Structure and Function of 1-Tetrahydrocannabinolic Acid (THCA) Synthase, the Enzyme Controlling the Psychoactivity of Cannabissativa.,Shoyama Y, Tamada T, Kurihara K, Takeuchi A, Taura F, Arai S, Blaber M, Shoyama Y, Morimoto S, Kuroki R J Mol Biol. 2012 Jul 2. PMID:22766313<ref>PMID:22766313</ref>
Structure and Function of 1-Tetrahydrocannabinolic Acid (THCA) Synthase, the Enzyme Controlling the Psychoactivity of Cannabissativa.,Shoyama Y, Tamada T, Kurihara K, Takeuchi A, Taura F, Arai S, Blaber M, Shoyama Y, Morimoto S, Kuroki R J Mol Biol. 2012 Jul 2. PMID:22766313<ref>PMID:22766313</ref>


From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 3vte" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Cansa]]
[[Category: Cannabis sativa]]
[[Category: Arai, S.]]
[[Category: Large Structures]]
[[Category: Blaber, M.]]
[[Category: Arai S]]
[[Category: Kurihara, K.]]
[[Category: Blaber M]]
[[Category: Kuroki, R.]]
[[Category: Kurihara K]]
[[Category: Morimoto, S.]]
[[Category: Kuroki R]]
[[Category: Shoyama, Y.]]
[[Category: Morimoto S]]
[[Category: Takeuchi, A.]]
[[Category: Shoyama Y]]
[[Category: Tamada, T.]]
[[Category: Takeuchi A]]
[[Category: Taura, F.]]
[[Category: Tamada T]]
[[Category: Bi-covalent flavinylation]]
[[Category: Taura F]]
[[Category: Oxidoreductase]]
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