3vxd: Difference between revisions
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==Crystal structure of unsaturated glucuronyl hydrolase mutant D115N from Streptcoccus agalactiae== | |||
<StructureSection load='3vxd' size='340' side='right'caption='[[3vxd]], [[Resolution|resolution]] 2.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3vxd]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_agalactiae_NEM316 Streptococcus agalactiae NEM316]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VXD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VXD FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | |||
== | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
[[3vxd]] is a 4 chain structure with sequence from [ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vxd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vxd OCA], [https://pdbe.org/3vxd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vxd RCSB], [https://www.ebi.ac.uk/pdbsum/3vxd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vxd ProSAT]</span></td></tr> | ||
[[ | </table> | ||
[[ | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/UCDH_STRA3 UCDH_STRA3] Catalyzes the hydrolysis of unsaturated hyaluronate and chondroitin disaccharides. Also degrades unsaturated heparin disaccharides. Releases 4-deoxy-4,5-didehydro D-glucuronic acid or 4-deoxy-4,5-didehydro L-iduronic acid from chondroitin disaccharides, hyaluronan disaccharides and heparin disaccharides and cleaves both glycosidic (1->3) and (1->4) bonds. Prefers sulfated glycosaminoglycans compared to unsulfated glycosaminoglycans. Probably required for mammalian cells invasion through the degradation of extracellular sulfated glycosaminoglycans such as chondroitin and hyaluronan.<ref>PMID:19416976</ref> <ref>PMID:21147778</ref> | ||
[[Category: | == References == | ||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Streptococcus agalactiae NEM316]] | |||
[[Category: Hashimoto W]] | |||
[[Category: Maruyama Y]] | |||
[[Category: Mikami B]] | |||
[[Category: Murata K]] | |||
[[Category: Nakamichi Y]] | |||
Latest revision as of 12:40, 8 November 2023
Crystal structure of unsaturated glucuronyl hydrolase mutant D115N from Streptcoccus agalactiae
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