3wvf: Difference between revisions
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The | ==Crystal structure of YidC from Escherichia coli== | ||
<StructureSection load='3wvf' size='340' side='right'caption='[[3wvf]], [[Resolution|resolution]] 3.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3wvf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_UTI89 Escherichia coli UTI89]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WVF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WVF FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wvf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wvf OCA], [https://pdbe.org/3wvf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wvf RCSB], [https://www.ebi.ac.uk/pdbsum/3wvf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wvf ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/YIDC_ECOUT YIDC_ECOUT] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Bacterial YidC, an evolutionally conserved membrane protein, functions as a membrane protein chaperone in cooperation with the Sec translocon and as an independent insertase for membrane proteins. In Gram-negative bacteria, the transmembrane and periplasmic regions of YidC interact with the Sec proteins, forming a multi-protein complex for Sec-dependent membrane protein integration. Here, we report the crystal structure of full-length Escherichia coli YidC. The structure reveals that a hydrophilic groove, formed by five transmembrane helices, is a conserved structural feature of YidC, as compared to the previous YidC structure from Bacillus halodurans, which lacks a periplasmic domain. Structural mapping of the substrate- or Sec protein-contact sites suggested the importance of the groove for the YidC functions as a chaperone and an insertase, and provided structural insight into the multi-protein complex. | |||
Crystal structure of Escherichia coli YidC, a membrane protein chaperone and insertase.,Kumazaki K, Kishimoto T, Furukawa A, Mori H, Tanaka Y, Dohmae N, Ishitani R, Tsukazaki T, Nureki O Sci Rep. 2014 Dec 3;4:7299. doi: 10.1038/srep07299. PMID:25466392<ref>PMID:25466392</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 3wvf" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Insertase|Insertase]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Escherichia coli UTI89]] | |||
[[Category: Large Structures]] | |||
[[Category: Ishitani R]] | |||
[[Category: Kishimoto T]] | |||
[[Category: Kumazaki K]] | |||
[[Category: Nureki O]] | |||
[[Category: Tsukazaki T]] | |||
Latest revision as of 13:30, 8 November 2023
Crystal structure of YidC from Escherichia coli
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