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==Crystal structure of Arginyl-tRNA synthetase complexed with L-arginine==
==Crystal structure of Arginyl-tRNA synthetase complexed with L-arginine==
<StructureSection load='4q2t' size='340' side='right' caption='[[4q2t]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='4q2t' size='340' side='right'caption='[[4q2t]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4q2t]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q2T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q2T FirstGlance]. <br>
<table><tr><td colspan='2'>[[4q2t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q2T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Q2T FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4q2x|4q2x]], [[4q2y|4q2y]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Arginine--tRNA_ligase Arginine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.19 6.1.1.19] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4q2t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q2t OCA], [https://pdbe.org/4q2t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4q2t RCSB], [https://www.ebi.ac.uk/pdbsum/4q2t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4q2t ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q2t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q2t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4q2t RCSB], [http://www.ebi.ac.uk/pdbsum/4q2t PDBsum]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SYRC_HUMAN SYRC_HUMAN]] Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis. Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1.<ref>PMID:17443684</ref>
[https://www.uniprot.org/uniprot/SYRC_HUMAN SYRC_HUMAN] Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis. Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1.<ref>PMID:17443684</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4q2t" style="background-color:#fffaf0;"></div>
==See Also==
*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Arginine--tRNA ligase]]
[[Category: Homo sapiens]]
[[Category: Cha, S Y]]
[[Category: Large Structures]]
[[Category: Han, A R]]
[[Category: Cha SY]]
[[Category: Hwang, K Y]]
[[Category: Han AR]]
[[Category: Jo, C H]]
[[Category: Hwang KY]]
[[Category: Kim, H S]]
[[Category: Jo CH]]
[[Category: Arginine binding]]
[[Category: Kim HS]]
[[Category: Arginine-trna ligase activity]]
[[Category: High region]]
[[Category: Ligase]]
[[Category: Trna binding]]

Latest revision as of 15:03, 8 November 2023

Crystal structure of Arginyl-tRNA synthetase complexed with L-arginine

4q2t, resolution 2.40Å

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