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==The crystal structure of the nucleosome containing cyclobutane pyrimidine dimer==
==The crystal structure of the nucleosome containing cyclobutane pyrimidine dimer==
<StructureSection load='5b24' size='340' side='right' caption='[[5b24]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
<StructureSection load='5b24' size='340' side='right'caption='[[5b24]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5b24]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5B24 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5B24 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5b24]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5B24 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5B24 FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TTD:CIS-SYN+CYCLOBUTANE+THYMINE+DIMER'>TTD</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.6&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5b24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5b24 OCA], [http://pdbe.org/5b24 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5b24 RCSB], [http://www.ebi.ac.uk/pdbsum/5b24 PDBsum]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TTD:CIS-SYN+CYCLOBUTANE+THYMINE+DIMER'>TTD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5b24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5b24 OCA], [https://pdbe.org/5b24 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5b24 RCSB], [https://www.ebi.ac.uk/pdbsum/5b24 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5b24 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/H2B1J_HUMAN H2B1J_HUMAN]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref>  Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref> 
[https://www.uniprot.org/uniprot/H31_HUMAN H31_HUMAN]  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5b24" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5b24" style="background-color:#fffaf0;"></div>
==See Also==
*[[Histone 3D structures|Histone 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Horikoshi, N]]
[[Category: Homo sapiens]]
[[Category: Kagawa, W]]
[[Category: Large Structures]]
[[Category: Kurumizaka, H]]
[[Category: Horikoshi N]]
[[Category: Osakabe, A]]
[[Category: Kagawa W]]
[[Category: Tachiwana, H]]
[[Category: Kurumizaka H]]
[[Category: Cpd]]
[[Category: Osakabe A]]
[[Category: Nucleosome]]
[[Category: Tachiwana H]]
[[Category: Photolesion]]
[[Category: Structural protein-dna complex]]

Latest revision as of 15:56, 8 November 2023

The crystal structure of the nucleosome containing cyclobutane pyrimidine dimer

5b24, resolution 3.60Å

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