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==Crystal structure of Izumo1, the mammalian sperm ligand for egg Juno==
==Crystal structure of Izumo1, the mammalian sperm ligand for egg Juno==
<StructureSection load='5b5k' size='340' side='right' caption='[[5b5k]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='5b5k' size='340' side='right'caption='[[5b5k]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5b5k]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5B5K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5B5K FirstGlance]. <br>
<table><tr><td colspan='2'>[[5b5k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5B5K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5B5K FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ejn|5ejn]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5b5k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5b5k OCA], [http://pdbe.org/5b5k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5b5k RCSB], [http://www.ebi.ac.uk/pdbsum/5b5k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5b5k ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5b5k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5b5k OCA], [https://pdbe.org/5b5k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5b5k RCSB], [https://www.ebi.ac.uk/pdbsum/5b5k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5b5k ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/IZUM1_MOUSE IZUM1_MOUSE]] Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'.<ref>PMID:15759005</ref> <ref>PMID:24739963</ref>
[https://www.uniprot.org/uniprot/IZUM1_MOUSE IZUM1_MOUSE] Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'.<ref>PMID:15759005</ref> <ref>PMID:24739963</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Han, L]]
[[Category: Large Structures]]
[[Category: Jovine, L]]
[[Category: Mus musculus]]
[[Category: Nishimura, K]]
[[Category: De Sanctis D]]
[[Category: Sanctis, D De]]
[[Category: Han L]]
[[Category: Cell adhesion]]
[[Category: Jovine L]]
[[Category: Egg receptor]]
[[Category: Nishimura K]]
[[Category: Fertilization]]
[[Category: Gamete adhesion]]
[[Category: Sperm-egg membrane fusion]]
Retrieved from "https://proteopedia.org/5b5k"