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==Crystal structure of Neanderthal Adenylosuccinate Lyase (ADSL)in complex with its products AICAR and fumarate==
==Crystal structure of Neanderthal Adenylosuccinate Lyase (ADSL)in complex with its products AICAR and fumarate==
<StructureSection load='5nxa' size='340' side='right' caption='[[5nxa]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='5nxa' size='340' side='right'caption='[[5nxa]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5nxa]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Feldhofer_1 Feldhofer 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NXA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NXA FirstGlance]. <br>
<table><tr><td colspan='2'>[[5nxa]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens_neanderthalensis Homo sapiens neanderthalensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NXA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NXA FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMZ:AMINOIMIDAZOLE+4-CARBOXAMIDE+RIBONUCLEOTIDE'>AMZ</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FUM:FUMARIC+ACID'>FUM</scene>, <scene name='pdbligand=SSS:N-{[5-AMINO-1-(5-O-PHOSPHONO-BETA-D-ARABINOFURANOSYL)-1H-IMIDAZOL-4-YL]CARBONYL}-L-ASPARTIC+ACID'>SSS</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ADSL, AMPS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=63221 Feldhofer 1])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMZ:AMINOIMIDAZOLE+4-CARBOXAMIDE+RIBONUCLEOTIDE'>AMZ</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FUM:FUMARIC+ACID'>FUM</scene>, <scene name='pdbligand=SSS:N-{[5-AMINO-1-(5-O-PHOSPHONO-BETA-D-ARABINOFURANOSYL)-1H-IMIDAZOL-4-YL]CARBONYL}-L-ASPARTIC+ACID'>SSS</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylosuccinate_lyase Adenylosuccinate lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.2.2 4.3.2.2] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5nxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nxa OCA], [https://pdbe.org/5nxa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5nxa RCSB], [https://www.ebi.ac.uk/pdbsum/5nxa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5nxa ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nxa OCA], [http://pdbe.org/5nxa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nxa RCSB], [http://www.ebi.ac.uk/pdbsum/5nxa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nxa ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A384E0N4_HOMNE A0A384E0N4_HOMNE] Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate.[ARBA:ARBA00002971]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5nxa" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5nxa" style="background-color:#fffaf0;"></div>
==See Also==
*[[Adenylosuccinate lyase 3D structures|Adenylosuccinate lyase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Adenylosuccinate lyase]]
[[Category: Homo sapiens neanderthalensis]]
[[Category: Feldhofer 1]]
[[Category: Large Structures]]
[[Category: Kapp, U]]
[[Category: Kapp U]]
[[Category: Laer, B Van]]
[[Category: Leonard G]]
[[Category: Leonard, G]]
[[Category: Mueller-Dieckmann C]]
[[Category: Mueller-Dieckmann, C]]
[[Category: Soler-Lopez M]]
[[Category: Soler-Lopez, M]]
[[Category: Van Laer B]]
[[Category: Fumarase]]
[[Category: Lyase]]
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