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[[Image:1b36.gif|left|200px]]
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{{STRUCTURE_1b36|  PDB=1b36  |  SCENE=  }}
'''SOLUTION STRUCTURE OF THE HAIRPIN RIBOZYME LOOP B DOMAIN RNA, NMR, 10 STRUCTURES'''


==SOLUTION STRUCTURE OF THE HAIRPIN RIBOZYME LOOP B DOMAIN RNA, NMR, 10 STRUCTURES==
<StructureSection load='1b36' size='340' side='right'caption='[[1b36]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1b36]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B36 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1B36 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1b36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b36 OCA], [https://pdbe.org/1b36 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1b36 RCSB], [https://www.ebi.ac.uk/pdbsum/1b36 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1b36 ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The hairpin ribozyme is a small catalytic RNA with a unique two-domain structure. Here we present the solution structure of the loop B domain of the hairpin ribozyme, which contains most of the catalytically essential nucleotides. The 38-nucleotide domain contains a 16-nucleotide internal loop that forms one of the largest non-Watson-Crick segments of base pairing thus far determined by either NMR or crystallography. Since the solution structure of the smaller loop A domain has been previously solved, an NMR structure-based model of the 22,000 Mr hairpin ribozyme-substrate open complex emerges by joining the two domain structures. Strikingly, catalytically essential functional groups for the loop B domain are concentrated within an expanded minor groove, presenting a clear docking surface for the loop A domain.


==Overview==
Solution structure of the loop B domain from the hairpin ribozyme.,Butcher SE, Allain FH, Feigon J Nat Struct Biol. 1999 Mar;6(3):212-6. PMID:10074938<ref>PMID:10074938</ref>
The hairpin ribozyme is a small catalytic RNA with a unique two-domain structure. Here we present the solution structure of the loop B domain of the hairpin ribozyme, which contains most of the catalytically essential nucleotides. The 38-nucleotide domain contains a 16-nucleotide internal loop that forms one of the largest non-Watson-Crick segments of base pairing thus far determined by either NMR or crystallography. Since the solution structure of the smaller loop A domain has been previously solved, an NMR structure-based model of the 22,000 Mr hairpin ribozyme-substrate open complex emerges by joining the two domain structures. Strikingly, catalytically essential functional groups for the loop B domain are concentrated within an expanded minor groove, presenting a clear docking surface for the loop A domain.


==About this Structure==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B36 OCA].
</div>
<div class="pdbe-citations 1b36" style="background-color:#fffaf0;"></div>


==Reference==
==See Also==
Solution structure of the loop B domain from the hairpin ribozyme., Butcher SE, Allain FH, Feigon J, Nat Struct Biol. 1999 Mar;6(3):212-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10074938 10074938]
*[[Ribozyme 3D structures|Ribozyme 3D structures]]
[[Category: Butcher, S E.]]
== References ==
[[Category: Dieckmann, T.]]
<references/>
[[Category: Feigon, J.]]
__TOC__
[[Category: Group i intron]]
</StructureSection>
[[Category: Group ii intron]]
[[Category: Large Structures]]
[[Category: Ribonucleic acid]]
[[Category: Synthetic construct]]
[[Category: Tetraloop receptor]]
[[Category: Butcher SE]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 11:00:06 2008''
[[Category: Dieckmann T]]
[[Category: Feigon J]]
Retrieved from "https://proteopedia.org/1b36"