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[[Image:1c8a.png|left|200px]]


{{STRUCTURE_1c8a| PDB=1c8a |  SCENE= }}
==NMR STRUCTURE OF INTRAMOLECULAR DIMER ANTIFREEZE PROTEIN RD3, 40 SA STRUCTURES==
<StructureSection load='1c8a' size='340' side='right'caption='[[1c8a]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1c8a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pachycara_brachycephalum Pachycara brachycephalum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C8A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1C8A FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1c8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c8a OCA], [https://pdbe.org/1c8a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1c8a RCSB], [https://www.ebi.ac.uk/pdbsum/1c8a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1c8a ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ANP3_LYCDA ANP3_LYCDA] Contributes to protect fish blood from freezing at subzero sea water temperatures. Lowers the blood freezing point. Binds to nascent ice crystals and prevents further growth (By similarity).
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The structure of a new antifreeze protein (AFP) variant, RD3, from antarctic eel pout (Rhigophila dearborni) with enhanced activity has been determined for the first time by nuclear magnetic resonance spectroscopy. RD3 comprises a unique translational topology of two homologous type III AFP globular domains, each containing one flat, ice binding plane. The ice binding plane of the N domain is located approximately 3.5 A "behind" that of the C domain. The two ice binding planes are located laterally with an angle of 32 +/- 12 degrees between the planes. These results suggest that the C domain plane of RD3 binds first to the ice [1010] prism plane in the &lt;0001&gt; direction, which induces successive ice binding of the N domain in the &lt;0101&gt; direction. This manner of ice binding caused by the unique structural topology of RD3 is thought to be crucial for the significant enhancement of antifreeze activity, especially at low AFP concentrations.


===NMR STRUCTURE OF INTRAMOLECULAR DIMER ANTIFREEZE PROTEIN RD3, 40 SA STRUCTURES===
NMR analysis of type III antifreeze protein intramolecular dimer. Structural basis for enhanced activity.,Miura K, Ohgiya S, Hoshino T, Nemoto N, Suetake T, Miura A, Spyracopoulos L, Kondo H, Tsuda S J Biol Chem. 2001 Jan 12;276(2):1304-10. PMID:11010977<ref>PMID:11010977</ref>


{{ABSTRACT_PUBMED_11010977}}
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
==About this Structure==
<div class="pdbe-citations 1c8a" style="background-color:#fffaf0;"></div>
[[1c8a]] is a 1 chain structure of [[Antifreeze protein]] with sequence from [http://en.wikipedia.org/wiki/Pachycara_brachycephalum Pachycara brachycephalum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C8A OCA].


==See Also==
==See Also==
*[[Antifreeze protein|Antifreeze protein]]
*[[Antifreeze protein 3D structures|Antifreeze protein 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:011010977</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Pachycara brachycephalum]]
[[Category: Pachycara brachycephalum]]
[[Category: Miura, K.]]
[[Category: Miura K]]
[[Category: Tsuda, S.]]
[[Category: Tsuda S]]
[[Category: Antifreeze]]
[[Category: Antifreeze protein]]
[[Category: Ice binding protein]]
[[Category: Thermal hysteresis protein]]
Retrieved from "https://proteopedia.org/1c8a"