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<StructureSection load='7brq' size='340' side='right'caption='[[7brq]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
<StructureSection load='7brq' size='340' side='right'caption='[[7brq]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[7brq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BRQ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7BRQ FirstGlance]. <br>
<table><tr><td colspan='2'>[[7brq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BRQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BRQ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.404&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[7brn|7brn]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GABARAP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7brq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7brq OCA], [https://pdbe.org/7brq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7brq RCSB], [https://www.ebi.ac.uk/pdbsum/7brq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7brq ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7brq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7brq OCA], [http://pdbe.org/7brq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7brq RCSB], [http://www.ebi.ac.uk/pdbsum/7brq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7brq ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/RETR1_HUMAN RETR1_HUMAN]] Hereditary sensory and autonomic neuropathy type 2. The disease is caused by mutations affecting the gene represented in this entry.  
[https://www.uniprot.org/uniprot/RETR1_HUMAN RETR1_HUMAN] Hereditary sensory and autonomic neuropathy type 2. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/RETR1_HUMAN RETR1_HUMAN]] Endoplasmic reticulum-anchored autophagy receptor that mediates ER delivery into lysosomes through sequestration into autophagosomes (PubMed:26040720). Promotes membrane remodeling and ER scission via its membrane bending capacity and targets the fragments into autophagosomes via interaction with ATG8 family proteins (PubMed:26040720). Required for long-term survival of nociceptive and autonomic ganglion neurons (PubMed:19838196, PubMed:26040720).<ref>PMID:19838196</ref> <ref>PMID:26040720</ref>
[https://www.uniprot.org/uniprot/GBRAP_HUMAN GBRAP_HUMAN] May play a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in apoptosis. Involved in autophagy (By similarity).<ref>PMID:15977068</ref> [https://www.uniprot.org/uniprot/RETR1_HUMAN RETR1_HUMAN] Endoplasmic reticulum-anchored autophagy receptor that mediates ER delivery into lysosomes through sequestration into autophagosomes (PubMed:26040720). Promotes membrane remodeling and ER scission via its membrane bending capacity and targets the fragments into autophagosomes via interaction with ATG8 family proteins (PubMed:26040720). Required for long-term survival of nociceptive and autonomic ganglion neurons (PubMed:19838196, PubMed:26040720).<ref>PMID:19838196</ref> <ref>PMID:26040720</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 7brq" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 7brq" style="background-color:#fffaf0;"></div>
==See Also==
*[[GABA receptor-associated protein 3D structures|GABA receptor-associated protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Noda, N N]]
[[Category: Noda NN]]
[[Category: Yamasaki, A]]
[[Category: Yamasaki A]]
[[Category: Autophagy]]
[[Category: Endoplasmic reticulum]]
[[Category: Membrane protein]]
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