7ebl: Difference between revisions
From Proteopedia
Jump to navigationJump to search
New page: '''Unreleased structure''' The entry 7ebl is ON HOLD Authors: Description: Category: Unreleased Structures |
No edit summary |
||
| (4 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
==Bacterial STING in complex with c-di-GMP== | |||
<StructureSection load='7ebl' size='340' side='right'caption='[[7ebl]], [[Resolution|resolution]] 2.17Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7ebl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Myroides_sp._ZB35 Myroides sp. ZB35]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EBL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EBL FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.17Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C2E:9,9-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d 3,2-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one)'>C2E</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ebl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ebl OCA], [https://pdbe.org/7ebl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ebl RCSB], [https://www.ebi.ac.uk/pdbsum/7ebl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ebl ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Mammalian innate immune sensor STING (STimulator of INterferon Gene) was recently found to originate from bacteria. During phage infection, bacterial STING sense c-di-GMP generated by the CD-NTase (cGAS/DncV-like nucleotidyltransferase) encoded in the same operon and signal suicide commitment as a defense strategy that restricts phage propagation. However, the precise binding mode of c-di-GMP to bacterial STING and the specific recognition mechanism are still elusive. Here, we determine two complex crystal structures of bacterial STING/c-di-GMP, which provide a clear picture of how c-di-GMP is distinguished from other cyclic dinucleotides. The protein-protein interactions further reveal the driving force behind filament formation of bacterial STING. Finally, we group the bacterial STING into two classes based on the conserved motif in beta-strand lid, which dictate their ligand specificity and oligomerization mechanism, and propose an evolution-based model that describes the transition from c-di-GMP-dependent signaling in bacteria to 2'3'-cGAMP-dependent signaling in eukaryotes. | |||
Crystal structure and functional implication of bacterial STING.,Ko TP, Wang YC, Yang CS, Hou MH, Chen CJ, Chiu YF, Chen Y Nat Commun. 2022 Jan 10;13(1):26. doi: 10.1038/s41467-021-26583-3. PMID:35013136<ref>PMID:35013136</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 7ebl" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Stimulator of interferon genes protein 3D structures|Stimulator of interferon genes protein 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Myroides sp. ZB35]] | |||
[[Category: Chen Y]] | |||
[[Category: Hou M-H]] | |||
[[Category: Ko T-P]] | |||
[[Category: Wang Y-C]] | |||
[[Category: Yang C-S]] | |||
Latest revision as of 16:50, 29 November 2023
Bacterial STING in complex with c-di-GMP
| ||||||||||||
