2c5h: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
 
(8 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:2c5h.png|left|200px]]


{{STRUCTURE_2c5h|  PDB=2c5h  |  SCENE=  }}
==X-ray crystal structure of 5'-fluorodeoxyadenosine synthase from Streptomyces cattleya complexed with 2'deoxy-adenosine==
 
<StructureSection load='2c5h' size='340' side='right'caption='[[2c5h]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
===X-RAY CRYSTAL STRUCTURE OF 5'-FLUORODEOXYADENOSINE SYNTHASE FROM STREPTOMYCES CATTLEYA COMPLEXED WITH 2'DEOXY-ADENOSINE===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2c5h]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_cattleya Streptomyces cattleya]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C5H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C5H FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
==About this Structure==
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3D1:(2R,3S,5R)-5-(6-AMINO-9H-PURIN-9-YL)-TETRAHYDRO-2-(HYDROXYMETHYL)FURAN-3-OL'>3D1</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MET:METHIONINE'>MET</scene></td></tr>
[[2c5h]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_cattleya Streptomyces cattleya]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C5H OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c5h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c5h OCA], [https://pdbe.org/2c5h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c5h RCSB], [https://www.ebi.ac.uk/pdbsum/2c5h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c5h ProSAT]</span></td></tr>
[[Category: Adenosyl-fluoride synthase]]
</table>
[[Category: Streptomyces cattleya]]
== Function ==
[[Category: Deng, H.]]
[https://www.uniprot.org/uniprot/FLA_STRCT FLA_STRCT] Involved in the biosynthesis of fluorometabolites. Catalyzes the formation of a C-F bond by combining S-adenosyl-L-methionine (SAM) and fluoride to generate 5'-fluoro-5'-deoxyadenosine (5'-FDA) and L-methionine. It can also use 2'-deoxyadenosine in place of adenosine as substrate.<ref>PMID:12860396</ref> <ref>PMID:14765200</ref> <ref>PMID:16370017</ref> <ref>PMID:16604208</ref> <ref>PMID:16720268</ref> <ref>PMID:17985882</ref>
[[Category: Hagan, D O.]]
== Evolutionary Conservation ==
[[Category: Mcewan, A R.]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: Mcglinchey, R P.]]
Check<jmol>
[[Category: Naismith, J H.]]
  <jmolCheckbox>
[[Category: Robinson, D R.]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c5/2c5h_consurf.spt"</scriptWhenChecked>
[[Category: Spencer, J.]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: 5'-fluorodeoxyadenosine synthase]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: Aza]]
  </jmolCheckbox>
[[Category: Fla]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c5h ConSurf].
[[Category: Fluorinase]]
<div style="clear:both"></div>
[[Category: Inhibitor]]
== References ==
[[Category: Sam analogue]]
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Streptomyces cattleya]]
[[Category: Streptomyces cattleya]]
[[Category: Transferase]]
[[Category: Deng H]]
[[Category: McEwan AR]]
[[Category: McGlinchey RP]]
[[Category: Naismith JH]]
[[Category: O'Hagan D]]
[[Category: Robinson DR]]
[[Category: Spencer J]]
Retrieved from "https://proteopedia.org/2c5h"