2cij: Difference between revisions
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==membrane-bound glutamate carboxypeptidase II (GCPII) with bound methionine== | |||
<StructureSection load='2cij' size='340' side='right'caption='[[2cij]], [[Resolution|resolution]] 2.40Å' scene=''> | |||
== | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2cij]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CIJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CIJ FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MET:METHIONINE'>MET</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
== | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cij FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cij OCA], [https://pdbe.org/2cij PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cij RCSB], [https://www.ebi.ac.uk/pdbsum/2cij PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cij ProSAT]</span></td></tr> | ||
[[2cij]] is a 1 chain structure | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/FOLH1_HUMAN FOLH1_HUMAN] Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Isoform PSM-4 and isoform PSM-5 would appear to be physiologically irrelevant. Involved in prostate tumor progression. Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC. | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ci/2cij_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cij ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | ==See Also== | ||
*[[Carboxypeptidase|Carboxypeptidase]] | *[[Carboxypeptidase 3D structures|Carboxypeptidase 3D structures]] | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Barinka | [[Category: Large Structures]] | ||
[[Category: Hilgenfeld | [[Category: Barinka C]] | ||
[[Category: Konvalinka | [[Category: Hilgenfeld R]] | ||
[[Category: Majer | [[Category: Konvalinka J]] | ||
[[Category: Mesters | [[Category: Majer P]] | ||
[[Category: Mlcochova | [[Category: Mesters JR]] | ||
[[Category: Plechanovova | [[Category: Mlcochova P]] | ||
[[Category: Rulisek | [[Category: Plechanovova A]] | ||
[[Category: Slusher | [[Category: Rulisek L]] | ||
[[Category: Slusher BS]] | |||
Latest revision as of 14:18, 13 December 2023
membrane-bound glutamate carboxypeptidase II (GCPII) with bound methionine
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