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==Bovine viral diarrhea virus CP7-R12 RNA-dependent RNA polymerase==
==Bovine viral diarrhea virus CP7-R12 RNA-dependent RNA polymerase==
<StructureSection load='2cjq' size='340' side='right' caption='[[2cjq]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='2cjq' size='340' side='right'caption='[[2cjq]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2cjq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bvdv Bvdv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CJQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CJQ FirstGlance]. <br>
<table><tr><td colspan='2'>[[2cjq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bovine_viral_diarrhea_virus_1 Bovine viral diarrhea virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CJQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CJQ FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ajj|2ajj]], [[2ajm|2ajm]], [[2ajn|2ajn]], [[2ajo|2ajo]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cjq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cjq OCA], [https://pdbe.org/2cjq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cjq RCSB], [https://www.ebi.ac.uk/pdbsum/2cjq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cjq ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cjq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cjq OCA], [http://pdbe.org/2cjq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cjq RCSB], [http://www.ebi.ac.uk/pdbsum/2cjq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2cjq ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/POLG_BVDVC POLG_BVDVC]] Initial binding to target cell probably involves interaction of E(rns) with glycosaminoglycans. E1 and/or E2 are responsible of cell attachment with CD46 and subsequent fusion after internalization of the virion by endocytosis (By similarity).  P7 forms a leader sequence to properly orient NS2 in the membrane (By similarity).  Uncleaved NS2-3 is required for production of infectious virus.  NS2 protease seems to play a vital role in viral RNA replication control and in the pathogenicity of the virus.  NS3 displays three enzymatic activities: serine protease, NTPase and RNA helicase.  NS4A is a cofactor for the NS3 protease activity (By similarity).  RNA-directed RNA polymerase NS5 replicates the viral (+) and (-) genome.  
[https://www.uniprot.org/uniprot/POLG_BVDVC POLG_BVDVC] Initial binding to target cell probably involves interaction of E(rns) with glycosaminoglycans. E1 and/or E2 are responsible of cell attachment with CD46 and subsequent fusion after internalization of the virion by endocytosis (By similarity).  P7 forms a leader sequence to properly orient NS2 in the membrane (By similarity).  Uncleaved NS2-3 is required for production of infectious virus.  NS2 protease seems to play a vital role in viral RNA replication control and in the pathogenicity of the virus.  NS3 displays three enzymatic activities: serine protease, NTPase and RNA helicase.  NS4A is a cofactor for the NS3 protease activity (By similarity).  RNA-directed RNA polymerase NS5 replicates the viral (+) and (-) genome.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
*[[RNA polymerase|RNA polymerase]]
*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bvdv]]
[[Category: Bovine viral diarrhea virus 1]]
[[Category: RNA-directed RNA polymerase]]
[[Category: Large Structures]]
[[Category: Becher, P]]
[[Category: Becher P]]
[[Category: Choi, K H]]
[[Category: Choi KH]]
[[Category: Gallei, A]]
[[Category: Gallei A]]
[[Category: Rossmann, M G]]
[[Category: Rossmann MG]]
[[Category: Atp-binding]]
[[Category: Bovine viral diarrhea virus]]
[[Category: Glycoprotein]]
[[Category: Helicase]]
[[Category: Hydrolase]]
[[Category: Membrane]]
[[Category: Nucleotide-binding]]
[[Category: Nucleotidyltransferase]]
[[Category: Polyprotein]]
[[Category: Protease]]
[[Category: Rna-dependent rna polymerase]]
[[Category: Rna-directed rna polymerase]]
[[Category: Serine protease]]
[[Category: Thiol protease]]
[[Category: Transferase]]
[[Category: Transmembrane]]
[[Category: Viral polymerase]]
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