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[[Image:2cls.gif|left|200px]]<br />
<applet load="2cls" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2cls, resolution 2.31&Aring;" />
'''THE CRYSTAL STRUCTURE OF THE HUMAN RND1 GTPASE IN THE ACTIVE GTP BOUND STATE'''<br />


==About this Structure==
==The crystal structure of the human RND1 GTPase in the active GTP bound state==
2CLS is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with MG and GTP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CLS OCA]].
<StructureSection load='2cls' size='340' side='right'caption='[[2cls]], [[Resolution|resolution]] 2.31&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2cls]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CLS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CLS FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.31&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cls FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cls OCA], [https://pdbe.org/2cls PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cls RCSB], [https://www.ebi.ac.uk/pdbsum/2cls PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cls ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RND1_HUMAN RND1_HUMAN] Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments.<ref>PMID:11095956</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cl/2cls_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cls ConSurf].
<div style="clear:both"></div>
 
==See Also==
*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
*[[Rho GTPase 3D structures|Rho GTPase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C.]]
[[Category: Arrowsmith C]]
[[Category: Bray, J.]]
[[Category: Bray J]]
[[Category: Colebrook, S.]]
[[Category: Colebrook S]]
[[Category: Debreczeni, J.E.]]
[[Category: Debreczeni JE]]
[[Category: Delft, F.Von.]]
[[Category: Doyle D]]
[[Category: Doyle, D.]]
[[Category: Edwards A]]
[[Category: Edwards, A.]]
[[Category: Elkins J]]
[[Category: Elkins, J.]]
[[Category: Gileadi O]]
[[Category: Gileadi, O.]]
[[Category: Marsden B]]
[[Category: Hwa, L.Wen.]]
[[Category: Pike ACW]]
[[Category: Marsden, B.]]
[[Category: Schoch G]]
[[Category: Pike, A.C.W.]]
[[Category: Sobott F]]
[[Category: Schoch, G.]]
[[Category: Sundstrom M]]
[[Category: Sobott, F.]]
[[Category: Turnbull AP]]
[[Category: Sundstrom, M.]]
[[Category: Weigelt J]]
[[Category: Turnbull, A.P.]]
[[Category: Wen Hwa L]]
[[Category: Weigelt, J.]]
[[Category: Yang X]]
[[Category: Yang, X.]]
[[Category: Zhao Y]]
[[Category: Zhao, Y.]]
[[Category: Von Delft F]]
[[Category: GTP]]
[[Category: MG]]
[[Category: cytoskeleton]]
[[Category: gtp-binding]]
[[Category: gtp-binding protein rho6]]
[[Category: lipoprotein]]
[[Category: membrane]]
[[Category: nucleotide binding protein]]
[[Category: nucleotide-binding]]
[[Category: polymorphism]]
[[Category: prenylation]]
[[Category: small gtpase]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:17:24 2007''

Latest revision as of 14:20, 13 December 2023

The crystal structure of the human RND1 GTPase in the active GTP bound state

2cls, resolution 2.31Å

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