2iwo: Difference between revisions
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==12th PDZ domain of Multiple PDZ Domain Protein MPDZ (CASP Target)== | ==12th PDZ domain of Multiple PDZ Domain Protein MPDZ (CASP Target)== | ||
<StructureSection load='2iwo' size='340' side='right' caption='[[2iwo]], [[Resolution|resolution]] 1.70Å' scene=''> | <StructureSection load='2iwo' size='340' side='right'caption='[[2iwo]], [[Resolution|resolution]] 1.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2iwo]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2iwo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IWO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IWO FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iwo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iwo OCA], [https://pdbe.org/2iwo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iwo RCSB], [https://www.ebi.ac.uk/pdbsum/2iwo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iwo ProSAT]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/MPDZ_HUMAN MPDZ_HUMAN] Interacts with HTR2C and provokes its clustering at the cell surface (By similarity). Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses.<ref>PMID:11150294</ref> <ref>PMID:15312654</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iw/2iwo_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iw/2iwo_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2iwo ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 2iwo" style="background-color:#fffaf0;"></div> | |||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Arrowsmith | [[Category: Large Structures]] | ||
[[Category: Berridge | [[Category: Arrowsmith C]] | ||
[[Category: Doyle | [[Category: Berridge G]] | ||
[[Category: Edwards | [[Category: Doyle DA]] | ||
[[Category: Elkins | [[Category: Edwards A]] | ||
[[Category: Gileadi | [[Category: Elkins JM]] | ||
[[Category: Johansson | [[Category: Gileadi C]] | ||
[[Category: Papagrigoriou | [[Category: Johansson C]] | ||
[[Category: Pike | [[Category: Papagrigoriou E]] | ||
[[Category: Savitsky | [[Category: Pike A]] | ||
[[Category: Schoch | [[Category: Savitsky P]] | ||
[[Category: Smee | [[Category: Schoch G]] | ||
[[Category: Sundstrom | [[Category: Smee CEA]] | ||
[[Category: Turnbull | [[Category: Sundstrom M]] | ||
[[Category: Weigelt | [[Category: Turnbull A]] | ||
[[Category: Yang | [[Category: Weigelt J]] | ||
[[Category: Yang X]] | |||
