2ja2: Difference between revisions
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==Mycobacterium tuberculosis glutamyl-tRNA synthetase== | |||
<StructureSection load='2ja2' size='340' side='right'caption='[[2ja2]], [[Resolution|resolution]] 1.65Å' scene=''> | |||
=== | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2ja2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JA2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JA2 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65Å</td></tr> | |||
== | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | ||
[[2ja2]] is a 1 chain structure | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ja2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ja2 OCA], [https://pdbe.org/2ja2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ja2 RCSB], [https://www.ebi.ac.uk/pdbsum/2ja2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ja2 ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/SYE_MYCTU SYE_MYCTU] Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity). | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ja/2ja2_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ja2 ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | ==See Also== | ||
*[[Aminoacyl tRNA | *[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]] | ||
[[Category: | __TOC__ | ||
[[Category: Mycobacterium tuberculosis]] | </StructureSection> | ||
[[Category: Bartunik | [[Category: Large Structures]] | ||
[[Category: Bourenkov | [[Category: Mycobacterium tuberculosis H37Rv]] | ||
[[Category: Bruning | [[Category: Bartunik HD]] | ||
[[Category: Shkolnaya | [[Category: Bourenkov GP]] | ||
[[Category: Strizhov | [[Category: Bruning M]] | ||
[[Category: Shkolnaya LA]] | |||
[[Category: Strizhov N]] | |||
Latest revision as of 14:40, 13 December 2023
Mycobacterium tuberculosis glutamyl-tRNA synthetase
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