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==Mouse Profilin IIa in complex with the proline-rich domain of VASP==
==Mouse Profilin IIa in complex with the proline-rich domain of VASP==
<StructureSection load='2v8c' size='340' side='right' caption='[[2v8c]], [[Resolution|resolution]] 1.98&Aring;' scene=''>
<StructureSection load='2v8c' size='340' side='right'caption='[[2v8c]], [[Resolution|resolution]] 1.98&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2v8c]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V8C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V8C FirstGlance]. <br>
<table><tr><td colspan='2'>[[2v8c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V8C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V8C FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.98&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2v8f|2v8f]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v8c OCA], [http://pdbe.org/2v8c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v8c RCSB], [http://www.ebi.ac.uk/pdbsum/2v8c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2v8c ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v8c OCA], [https://pdbe.org/2v8c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v8c RCSB], [https://www.ebi.ac.uk/pdbsum/2v8c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v8c ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PROF2_MOUSE PROF2_MOUSE]] Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. [[http://www.uniprot.org/uniprot/VASP_MOUSE VASP_MOUSE]] Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation (By similarity).<ref>PMID:10660044</ref> 
[https://www.uniprot.org/uniprot/PROF2_MOUSE PROF2_MOUSE] Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
*[[Profilin|Profilin]]
*[[Profilin 3D Structures|Profilin 3D Structures]]
*[[Vasodilator-stimulated phosphoprotein|Vasodilator-stimulated phosphoprotein]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Lk3 transgenic mice]]
[[Category: Large Structures]]
[[Category: Downer, J]]
[[Category: Mus musculus]]
[[Category: Kursula, P]]
[[Category: Downer J]]
[[Category: Wilmanns, M]]
[[Category: Kursula P]]
[[Category: Witke, W]]
[[Category: Wilmanns M]]
[[Category: Acetylation]]
[[Category: Witke W]]
[[Category: Actin-binding]]
[[Category: Alternative splicing]]
[[Category: Cytoplasm]]
[[Category: Cytoskeleton]]
[[Category: Protein binding]]
[[Category: Protein-binding]]
Retrieved from "https://proteopedia.org/2v8c"