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[[Image:2v8z.png|left|200px]]


{{STRUCTURE_2v8z|  PDB=2v8z  |  SCENE= }}
==Crystal Structure of YagE, a prophage protein belonging to the dihydrodipicolinic acid synthase family from E. coli K12==
 
<StructureSection load='2v8z' size='340' side='right'caption='[[2v8z]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
===CRYSTAL STRUCTURE OF YAGE, A PROPHAGE PROTEIN BELONGING TO THE DIHYDRODIPICOLINIC ACID SYNTHASE FAMILY FROM E. COLI K12===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2v8z]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V8Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V8Z FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v8z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v8z OCA], [https://pdbe.org/2v8z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v8z RCSB], [https://www.ebi.ac.uk/pdbsum/2v8z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v8z ProSAT]</span></td></tr>
[[2v8z]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V8Z OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/YAGE_ECOLI YAGE_ECOLI] Catalyzes the formation of 2-keto-3-deoxy-galactonate (KDGal) from pyruvate and glyceraldehyde. Overexpression leads to increased growth (over 2 hours) in the presence of the antibiotics norfloxacin, ampicillin and streptomycin.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v8/2v8z_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v8z ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Dihydrodipicolinate synthase|Dihydrodipicolinate synthase]]
*[[Dihydrodipicolinate synthase|Dihydrodipicolinate synthase]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:018361457</ref><references group="xtra"/>
[[Category: Escherichia coli K-12]]
[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Albeck, S.]]
[[Category: Albeck S]]
[[Category: Bourenkov, G.]]
[[Category: Bourenkov G]]
[[Category: Dym, O.]]
[[Category: Dym O]]
[[Category: Greenblatt, H M.]]
[[Category: Greenblatt HM]]
[[Category: Krishnaswamy, S.]]
[[Category: Krishnaswamy S]]
[[Category: Lamzin, V.]]
[[Category: Lamzin V]]
[[Category: Manicka, S.]]
[[Category: Manicka S]]
[[Category: Peleg, Y.]]
[[Category: Peleg Y]]
[[Category: Sussman, J L.]]
[[Category: Sussman JL]]
[[Category: Unger, T.]]
[[Category: Unger T]]
[[Category: Dhdp]]
[[Category: Lyase]]
[[Category: N-acetyl neuraminate lyase]]
[[Category: Nal]]

Latest revision as of 15:10, 13 December 2023

Crystal Structure of YagE, a prophage protein belonging to the dihydrodipicolinic acid synthase family from E. coli K12

2v8z, resolution 2.20Å

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