2v90: Difference between revisions

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[[Image:2v90.jpg|left|200px]]


{{Structure
==Crystal structure of the 3rd PDZ domain of intestine- and kidney- enriched PDZ domain IKEPP (PDZD3)==
|PDB= 2v90 |SIZE=350|CAPTION= <scene name='initialview01'>2v90</scene>, resolution 2.00&Aring;
<StructureSection load='2v90' size='340' side='right'caption='[[2v90]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
|SITE= <scene name='pdbsite=AC1:So4+Binding+Site+For+Chain+B'>AC1</scene>
== Structural highlights ==
|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
<table><tr><td colspan='2'>[[2v90]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V90 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V90 FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v90 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v90 OCA], [https://pdbe.org/2v90 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v90 RCSB], [https://www.ebi.ac.uk/pdbsum/2v90 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v90 ProSAT]</span></td></tr>
|RELATEDENTRY=
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v90 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v90 OCA], [http://www.ebi.ac.uk/pdbsum/2v90 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2v90 RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/NHRF4_HUMAN NHRF4_HUMAN] Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation (PubMed:11950846). Stimulates SLC9A3 activity in the presence of elevated calcium ions (PubMed:19088451).<ref>PMID:11950846</ref> <ref>PMID:19088451</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v9/2v90_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v90 ConSurf].
<div style="clear:both"></div>


'''CRYSTAL STRUCTURE OF THE 3RD PDZ DOMAIN OF INTESTINE- AND KIDNEY-ENRICHED PDZ DOMAIN IKEPP (PDZD3)'''
==See Also==
 
*[[Sodium-hydrogen exchange regulatory factor 3D structures|Sodium-hydrogen exchange regulatory factor 3D structures]]
 
== References ==
==About this Structure==
<references/>
2V90 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V90 OCA].
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H.]]
[[Category: Arrowsmith CH]]
[[Category: Bunkoczi, G.]]
[[Category: Bunkoczi G]]
[[Category: Cooper, C.]]
[[Category: Cooper C]]
[[Category: Doyle, D A.]]
[[Category: Doyle DA]]
[[Category: Edwards, A.]]
[[Category: Edwards A]]
[[Category: Elkins, J.]]
[[Category: Elkins J]]
[[Category: Gileadi, C.]]
[[Category: Gileadi C]]
[[Category: Phillips, C.]]
[[Category: Phillips C]]
[[Category: Pike, A C.W.]]
[[Category: Pike ACW]]
[[Category: Salah, E.]]
[[Category: Salah E]]
[[Category: Sundstrom, M.]]
[[Category: Sundstrom M]]
[[Category: Ugochukwu, E.]]
[[Category: Ugochukwu E]]
[[Category: Uppenberg, J.]]
[[Category: Uppenberg J]]
[[Category: Weigelt, J.]]
[[Category: Weigelt J]]
[[Category: alternative splicing]]
[[Category: cytoplasm]]
[[Category: membrane]]
[[Category: pdz domain]]
[[Category: pdzd3]]
[[Category: protein-binding]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:09:45 2008''
Retrieved from "https://proteopedia.org/2v90"