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==STRUCTURE OF THE CALCIUM CHANNEL BLOCKER OMEGA CONOTOXIN GVIA, NMR, 20 STRUCTURES==
==STRUCTURE OF THE CALCIUM CHANNEL BLOCKER OMEGA CONOTOXIN GVIA, NMR, 20 STRUCTURES==
<StructureSection load='2cco' size='340' side='right' caption='[[2cco]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2cco' size='340' side='right'caption='[[2cco]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2cco]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Conus_geographus Conus geographus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1cco 1cco]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CCO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CCO FirstGlance]. <br>
<table><tr><td colspan='2'>[[2cco]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_geographus Conus geographus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1cco 1cco]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CCO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CCO FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cco OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cco RCSB], [http://www.ebi.ac.uk/pdbsum/2cco PDBsum]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
<table>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cco OCA], [https://pdbe.org/2cco PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cco RCSB], [https://www.ebi.ac.uk/pdbsum/2cco PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cco ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/O16A_CONGE O16A_CONGE] Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav). This toxin blocks N-type calcium channels (Cav2.2/CACNA1B) with a high potency (it displaces [125I]GVIA with an IC(50)=3.7-38 pM) (PubMed:10938268, PubMed:11724570).<ref>PMID:10938268</ref> <ref>PMID:11724570</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 2cco" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Conus geographus]]
[[Category: Conus geographus]]
[[Category: Norton, R S.]]
[[Category: Large Structures]]
[[Category: Pallaghy, P K.]]
[[Category: Norton RS]]
[[Category: Calcium channel blocker]]
[[Category: Pallaghy PK]]
[[Category: Cone-shell]]
[[Category: Conotoxin]]
[[Category: Cystine knot]]
[[Category: Inhibitor cystine knot motif]]
[[Category: Toxin]]
Retrieved from "https://proteopedia.org/2cco"