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==Structure of the M3 Muscarinic Acetylcholine Receptor Basolateral Sorting Signal==
==Structure of the M3 Muscarinic Acetylcholine Receptor Basolateral Sorting Signal==
<StructureSection load='2csa' size='340' side='right' caption='[[2csa]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
<StructureSection load='2csa' size='340' side='right'caption='[[2csa]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2csa]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CSA FirstGlance]. <br>
<table><tr><td colspan='2'>[[2csa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CSA FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2csa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2csa OCA], [http://pdbe.org/2csa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2csa RCSB], [http://www.ebi.ac.uk/pdbsum/2csa PDBsum]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2csa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2csa OCA], [https://pdbe.org/2csa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2csa RCSB], [https://www.ebi.ac.uk/pdbsum/2csa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2csa ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/ACM3_HUMAN ACM3_HUMAN]] Defects in CHRM3 are the cause of Eagle-Barrett syndrome (EGBRS) [MIM:[http://omim.org/entry/100100 100100]]. EGBRS is a syndrome characterized by thin abdominal musculature with overlying lax skin, cryptorchism, megacystis with disorganized detrusor muscle, and urinary tract abnormalities.<ref>PMID:22077972</ref>
[https://www.uniprot.org/uniprot/ACM3_HUMAN ACM3_HUMAN] Defects in CHRM3 are the cause of Eagle-Barrett syndrome (EGBRS) [MIM:[https://omim.org/entry/100100 100100]. EGBRS is a syndrome characterized by thin abdominal musculature with overlying lax skin, cryptorchism, megacystis with disorganized detrusor muscle, and urinary tract abnormalities.<ref>PMID:22077972</ref>  
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ACM3_HUMAN ACM3_HUMAN]] The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.  
[https://www.uniprot.org/uniprot/ACM3_HUMAN ACM3_HUMAN] The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Fox, D]]
[[Category: Homo sapiens]]
[[Category: Iverson, H A]]
[[Category: Large Structures]]
[[Category: Klevit, R E]]
[[Category: Fox D]]
[[Category: Nadler, L S]]
[[Category: Iverson HA]]
[[Category: Nathanson, N M]]
[[Category: Klevit RE]]
[[Category: Basolateral sorting-signal blss beta-turn]]
[[Category: Nadler LS]]
[[Category: Signaling protein-membrane protein complex]]
[[Category: Nathanson NM]]