2xe0: Difference between revisions
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<StructureSection load='2xe0' size='340' side='right' caption='[[2xe0]], [[Resolution|resolution]] 2.31Å' scene=''> | ==Molecular basis of engineered meganuclease targeting of the endogenous human RAG1 locus== | ||
<StructureSection load='2xe0' size='340' side='right'caption='[[2xe0]], [[Resolution|resolution]] 2.31Å' scene=''> | |||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2xe0]] is a 4 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2xe0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Chlamydomonas_reinhardtii Chlamydomonas reinhardtii] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XE0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XE0 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PGO:S-1,2-PROPANEDIOL'>PGO</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.31Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PGO:S-1,2-PROPANEDIOL'>PGO</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xe0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xe0 OCA], [https://pdbe.org/2xe0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xe0 RCSB], [https://www.ebi.ac.uk/pdbsum/2xe0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xe0 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
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Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xe/2xe0_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xe/2xe0_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2xe0 ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 2xe0" style="background-color:#fffaf0;"></div> | |||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Chlamydomonas reinhardtii]] | [[Category: Chlamydomonas reinhardtii]] | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Alibes | [[Category: Large Structures]] | ||
[[Category: Blanco | [[Category: Alibes A]] | ||
[[Category: Chion-Sotine | [[Category: Blanco FJ]] | ||
[[Category: Coloma | [[Category: Chion-Sotine I]] | ||
[[Category: Daboussi | [[Category: Coloma J]] | ||
[[Category: Duchateau | [[Category: D'Abramo M]] | ||
[[Category: Gervasio | [[Category: Daboussi F]] | ||
[[Category: Grizot | [[Category: Duchateau P]] | ||
[[Category: Marenchino | [[Category: Gervasio FL]] | ||
[[Category: Merino | [[Category: Grizot S]] | ||
[[Category: Montoya | [[Category: Marenchino M]] | ||
[[Category: Munoz | [[Category: Merino N]] | ||
[[Category: Paques | [[Category: Montoya G]] | ||
[[Category: Prieto | [[Category: Munoz IG]] | ||
[[Category: Redondo | [[Category: Paques F]] | ||
[[Category: Serrano | [[Category: Prieto J]] | ||
[[Category: Smith | [[Category: Redondo P]] | ||
[[Category: Stricher | [[Category: Serrano L]] | ||
[[Category: Subramanian | [[Category: Smith J]] | ||
[[Category: Villate | [[Category: Stricher F]] | ||
[[Category: Subramanian S]] | |||
[[Category: Villate M]] | |||
