4bzp: Difference between revisions
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==Structure of the Mycobacterium tuberculosis APS kinase CysC in complex with ADP== | ==Structure of the Mycobacterium tuberculosis APS kinase CysC in complex with ADP== | ||
<StructureSection load='4bzp' size='340' side='right' caption='[[4bzp]], [[Resolution|resolution]] 1.47Å' scene=''> | <StructureSection load='4bzp' size='340' side='right'caption='[[4bzp]], [[Resolution|resolution]] 1.47Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4bzp]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BZP OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[4bzp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BZP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BZP FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.47Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bzp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bzp OCA], [https://pdbe.org/4bzp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bzp RCSB], [https://www.ebi.ac.uk/pdbsum/4bzp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bzp ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/A5U1Y4_MYCTA A5U1Y4_MYCTA] APS kinase catalyzes the synthesis of activated sulfate.[ARBA:ARBA00002357] Catalyzes the synthesis of activated sulfate.[HAMAP-Rule:MF_00065] With CysD forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.[HAMAP-Rule:MF_00062] | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Lohkamp | [[Category: Mycobacterium tuberculosis]] | ||
[[Category: Poyraz | [[Category: Lohkamp B]] | ||
[[Category: Schneider | [[Category: Poyraz O]] | ||
[[Category: Schnell | [[Category: Schneider G]] | ||
[[Category: Schnell R]] | |||
