1b4y: Difference between revisions

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{{Seed}}
[[Image:1b4y.png|left|200px]]


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==STRUCTURE AND MECHANISM OF FORMATION OF THE H-Y5 ISOMER OF AN INTRAMOLECULAR DNA TRIPLE HELIX.==
The line below this paragraph, containing "STRUCTURE_1b4y", creates the "Structure Box" on the page.
<StructureSection load='1b4y' size='340' side='right'caption='[[1b4y]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1b4y]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B4Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1B4Y FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1b4y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b4y OCA], [https://pdbe.org/1b4y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1b4y RCSB], [https://www.ebi.ac.uk/pdbsum/1b4y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1b4y ProSAT]</span></td></tr>
{{STRUCTURE_1b4y|  PDB=1b4y  |  SCENE=  }}
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
H-DNA, thought to play a regulatory role in transcription, exists in two isomeric forms, H-y3 and H-y5. We present the first solution structure of a DNA fragment representing the H-y5 fold. The structure shows the H-y5 triple helix, and for the first time how in an H-DNA isomer the purine strand extension interacts with the triplex loop. It gives direct insight into the mechanism of H-DNA formation, and explains a host of biochemical and biophysical data on the relative stability of the H-DNA isomers. In addition, the observed interaction of the purine strand extension and the triplex loop provides new clues to the design of clamp-type triple helix-forming oligonucleotides.


===STRUCTURE AND MECHANISM OF FORMATION OF THE H-Y5 ISOMER OF AN INTRAMOLECULAR DNA TRIPLE HELIX.===
Structure and mechanism of formation of the H-y5 isomer of an intramolecular DNA triple helix.,van Dongen MJ, Doreleijers JF, van der Marel GA, van Boom JH, Hilbers CW, Wijmenga SS Nat Struct Biol. 1999 Sep;6(9):854-9. PMID:10467098<ref>PMID:10467098</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The line below this paragraph, {{ABSTRACT_PUBMED_10467098}}, adds the Publication Abstract to the page
<div class="pdbe-citations 1b4y" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 10467098 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_10467098}}
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</StructureSection>
==About this Structure==
[[Category: Large Structures]]
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B4Y OCA].
[[Category: Doreleijers JF]]
 
[[Category: Hilbers CW]]
==Reference==
[[Category: Van Boom JH]]
Structure and mechanism of formation of the H-y5 isomer of an intramolecular DNA triple helix., van Dongen MJ, Doreleijers JF, van der Marel GA, van Boom JH, Hilbers CW, Wijmenga SS, Nat Struct Biol. 1999 Sep;6(9):854-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10467098 10467098]
[[Category: Van Der Marel GA]]
[[Category: Boom, J H.Van.]]
[[Category: Van Dongen MJP]]
[[Category: Dongen, M J.P Van.]]
[[Category: Wijmenga SS]]
[[Category: Doreleijers, J F.]]
[[Category: Hilbers, C W.]]
[[Category: Marel, G A.Van Der.]]
[[Category: Wijmenga, S S.]]
[[Category: Dna]]
[[Category: H-dna]]
[[Category: Triple helix]]
 
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