1co4: Difference between revisions

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{{Seed}}
[[Image:1co4.png|left|200px]]


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==SOLUTION STRUCTURE OF A ZINC DOMAIN CONSERVED IN YEAST COPPER-REGULATED TRANSCRIPTION FACTORS==
The line below this paragraph, containing "STRUCTURE_1co4", creates the "Structure Box" on the page.
<StructureSection load='1co4' size='340' side='right'caption='[[1co4]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1co4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_glabrata_CBS_138 Candida glabrata CBS 138]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CO4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CO4 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_1co4|  PDB=1co4  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1co4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1co4 OCA], [https://pdbe.org/1co4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1co4 RCSB], [https://www.ebi.ac.uk/pdbsum/1co4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1co4 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/AMT1_CANGA AMT1_CANGA] Trans-acting regulatory protein that activates transcription of the MT genes (metallothionein) in response to copper or silver ions.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/co/1co4_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1co4 ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The three dimensional structure of the N-terminal domain (residues 1-42) of the copper-responsive transcription factor Amtl from Candida glabrata has been determined by two-dimensional 1H-correlated nuclear magnetic resonance (NMR) methods. The domain contains an array of zinc-binding residues (Cys-X2-Cys-X8-Cys-X-His) that is conserved among a family of Cu-responsive transcription factors. The structure is unlike those of previously characterized zinc finger motifs, and consists of a three-stranded antiparallel beta-sheet with two short helical segments that project from one end of the beta-sheet. Conserved residues at positions 16, 18 and 19 form a basic patch that may be important for DNA binding.


===SOLUTION STRUCTURE OF A ZINC DOMAIN CONSERVED IN YEAST COPPER-REGULATED TRANSCRIPTION FACTORS===
Solution structure of a zinc domain conserved in yeast copper-regulated transcription factors.,Turner RB, Smith DL, Zawrotny ME, Summers MF, Posewitz MC, Winge DR Nat Struct Biol. 1998 Jul;5(7):551-5. PMID:9665167<ref>PMID:9665167</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
The line below this paragraph, {{ABSTRACT_PUBMED_9665167}}, adds the Publication Abstract to the page
<div class="pdbe-citations 1co4" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 9665167 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_9665167}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Large Structures]]
1CO4 is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CO4 OCA].
[[Category: Posewitz MC]]
 
[[Category: Smith DL]]
==Reference==
[[Category: Summers MF]]
Solution structure of a zinc domain conserved in yeast copper-regulated transcription factors., Turner RB, Smith DL, Zawrotny ME, Summers MF, Posewitz MC, Winge DR, Nat Struct Biol. 1998 Jul;5(7):551-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9665167 9665167]
[[Category: Turner RB]]
[[Category: Single protein]]
[[Category: Winge DR]]
[[Category: Posewitz, M C.]]
[[Category: Zawrotny ME]]
[[Category: Smith, D L.]]
[[Category: Summers, M F.]]
[[Category: Turner, R B.]]
[[Category: Winge, D R.]]
[[Category: Zawrotny, M E.]]
[[Category: Amt]]
[[Category: Metal regulation]]
[[Category: Metallothionein]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 21:00:35 2008''

Latest revision as of 23:28, 27 December 2023

SOLUTION STRUCTURE OF A ZINC DOMAIN CONSERVED IN YEAST COPPER-REGULATED TRANSCRIPTION FACTORS

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