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New page: left|200px<br /><applet load="1ix1" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ix1, resolution 1.85Å" /> '''Crystal Structure of...
 
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[[Image:1ix1.gif|left|200px]]<br /><applet load="1ix1" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1ix1, resolution 1.85&Aring;" />
'''Crystal Structure of P.aeruginosa Peptide deformylase Complexed with Antibiotic Actinonin'''<br />


==About this Structure==
==Crystal Structure of P.aeruginosa Peptide deformylase Complexed with Antibiotic Actinonin==
1IX1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa] with ZN, BB2 and MHA as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Peptide_deformylase Peptide deformylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.88 3.5.1.88] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1IX1 OCA].  
<StructureSection load='1ix1' size='340' side='right'caption='[[1ix1]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
 
== Structural highlights ==
==Reference==
<table><tr><td colspan='2'>[[1ix1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IX1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IX1 FirstGlance]. <br>
Crystal structure of peptide deformylase from Staphylococcus aureus in complex with actinonin, a naturally occurring antibacterial agent., Yoon HJ, Kim HL, Lee SK, Kim HW, Kim HW, Lee JY, Mikami B, Suh SW, Proteins. 2004 Nov 15;57(3):639-42. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15382235 15382235]
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
[[Category: Peptide deformylase]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BB2:ACTINONIN'>BB2</scene>, <scene name='pdbligand=MHA:(CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC+ACID'>MHA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ix1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ix1 OCA], [https://pdbe.org/1ix1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ix1 RCSB], [https://www.ebi.ac.uk/pdbsum/1ix1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ix1 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DEF_PSEAE DEF_PSEAE] Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ix/1ix1_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ix1 ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Single protein]]
[[Category: Ahn HJ]]
[[Category: Ahn, H.J.]]
[[Category: Han BW]]
[[Category: Han, B.W.]]
[[Category: Kim H-W]]
[[Category: Kim, H.W.]]
[[Category: Lee BI]]
[[Category: Lee, B.I.]]
[[Category: Lee HH]]
[[Category: Lee, H.H.]]
[[Category: Lee JY]]
[[Category: Lee, J.Y.]]
[[Category: Suh SW]]
[[Category: Suh, S.W.]]
[[Category: Yang JK]]
[[Category: Yang, J.K.]]
[[Category: Yoon H-J]]
[[Category: Yoon, H.J.]]
[[Category: BB2]]
[[Category: MHA]]
[[Category: ZN]]
[[Category: protein-inhibitor complex]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 17:44:12 2007''
Retrieved from "https://proteopedia.org/1ix1"