1v9e: Difference between revisions

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{{Seed}}
[[Image:1v9e.png|left|200px]]


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==Crystal Structure Analysis of Bovine Carbonic Anhydrase II==
The line below this paragraph, containing "STRUCTURE_1v9e", creates the "Structure Box" on the page.
<StructureSection load='1v9e' size='340' side='right'caption='[[1v9e]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1v9e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V9E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1V9E FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_1v9e|  PDB=1v9e  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1v9e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v9e OCA], [https://pdbe.org/1v9e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1v9e RCSB], [https://www.ebi.ac.uk/pdbsum/1v9e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1v9e ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CAH2_BOVIN CAH2_BOVIN] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v9/1v9e_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1v9e ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Carbonic anhydrase (CA) is a zinc-containing enzyme that catalyzes the reversible hydration of CO2 to HCO3-. In eukaryotes, the enzyme plays a role in various physiological functions, including interconversion between CO2 and HCO3- in intermediary metabolism, facilitated diffusion of CO2, pH homeostasis and ion transport. The structure of bovine carbonic anhydrase II (BCA II) has been determined by molecular replacement and refined to 1.95 A resolution by simulated-annealing and individual B-factor refinement. The final R factor for the BCA II structure was 19.4%. BCA II has a C-terminal knot structure similar to that observed in human CA II. It contains one zinc ion in the active site coordinated to three histidines and one putative water molecule in a tetrahedral geometry. The structure of BCA II reveals a probable alternative proton-wire pathway that differs from that of HCA II.


===Crystal Structure Analysis of Bovine Carbonic Anhydrase II===
Structure of bovine carbonic anhydrase II at 1.95 A resolution.,Saito R, Sato T, Ikai A, Tanaka N Acta Crystallogr D Biol Crystallogr. 2004 Apr;60(Pt 4):792-5. Epub 2004, Mar 23. PMID:15039588<ref>PMID:15039588</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1v9e" style="background-color:#fffaf0;"></div>


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==See Also==
The line below this paragraph, {{ABSTRACT_PUBMED_15039588}}, adds the Publication Abstract to the page
*[[Carbonic anhydrase 3D structures|Carbonic anhydrase 3D structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 15039588 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_15039588}}
__TOC__
 
</StructureSection>
==About this Structure==
1V9E is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V9E OCA].
 
==Reference==
Structure of bovine carbonic anhydrase II at 1.95 A resolution., Saito R, Sato T, Ikai A, Tanaka N, Acta Crystallogr D Biol Crystallogr. 2004 Apr;60(Pt 4):792-5. Epub 2004, Mar 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15039588 15039588]
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Carbonate dehydratase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Ikai A]]
[[Category: Ikai, A.]]
[[Category: Saito R]]
[[Category: Saito, R.]]
[[Category: Sato T]]
[[Category: Sato, T.]]
[[Category: Tanaka N]]
[[Category: Tanaka, N.]]
[[Category: High-resolution]]
[[Category: Twisted beta sheet]]
[[Category: Zinc metalloenzyme]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 10:23:18 2008''

Latest revision as of 00:00, 28 December 2023

Crystal Structure Analysis of Bovine Carbonic Anhydrase II

1v9e, resolution 1.95Å

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