2o4v: Difference between revisions

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{{Seed}}
[[Image:2o4v.png|left|200px]]


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==An arginine ladder in OprP mediates phosphate specific transfer across the outer membrane==
The line below this paragraph, containing "STRUCTURE_2o4v", creates the "Structure Box" on the page.
<StructureSection load='2o4v' size='340' side='right'caption='[[2o4v]], [[Resolution|resolution]] 1.94&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2o4v]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O4V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O4V FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.94&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C8E:(HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE'>C8E</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
{{STRUCTURE_2o4v|  PDB=2o4v  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o4v OCA], [https://pdbe.org/2o4v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o4v RCSB], [https://www.ebi.ac.uk/pdbsum/2o4v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o4v ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PORP_PSEAE PORP_PSEAE] Anion specific, the binding site has higher affinity for phosphate than chloride ions. Porin O has a higher affinity for polyphosphates (tripolyphosphate and pyrophosphate) while porin P has a higher affinity for orthophosphate.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o4/2o4v_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2o4v ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The outer membrane protein OprP mediates the transport of essential phosphate anions into the pathogenic bacterium Pseudomonas aeruginosa. Here we report the crystallographic structure of trimeric OprP at 1.9-A resolution, revealing an unprecedented 9-residue arginine 'ladder' that spans from the extracellular surface down through a constriction zone where phosphate is coordinated. Lysine residues coat the inner periplasmic surface, creating an 'electropositive sink' that pulls the phosphates through the eyelet and into the cell.


===An arginine ladder in OprP mediates phosphate specific transfer across the outer membrane===
An arginine ladder in OprP mediates phosphate-specific transfer across the outer membrane.,Moraes TF, Bains M, Hancock RE, Strynadka NC Nat Struct Mol Biol. 2007 Jan;14(1):85-7. Epub 2006 Dec 24. PMID:17187075<ref>PMID:17187075</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2o4v" style="background-color:#fffaf0;"></div>


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==See Also==
The line below this paragraph, {{ABSTRACT_PUBMED_17187075}}, adds the Publication Abstract to the page
*[[Porin 3D structures|Porin 3D structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 17187075 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_17187075}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Large Structures]]
2O4V is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O4V OCA].
[[Category: Pseudomonas aeruginosa PAO1]]
 
[[Category: Bains M]]
==Reference==
[[Category: Hancock RE]]
<ref group="xtra">PMID:17187075</ref><references group="xtra"/>
[[Category: Moraes TF]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Strynadka NC]]
[[Category: Bains, M.]]
[[Category: Hancock, R E.]]
[[Category: Moraes, T F.]]
[[Category: Strynadka, N C.]]
[[Category: Channel]]
[[Category: Outer membrane]]
[[Category: Phosphate]]
[[Category: Porin]]
[[Category: Transport]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 18:56:34 2009''

Latest revision as of 00:14, 28 December 2023

An arginine ladder in OprP mediates phosphate specific transfer across the outer membrane

2o4v, resolution 1.94Å

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