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==Human mesotrypsin complexed with HAI-2 Kunitz domain 1==
==Human mesotrypsin complexed with HAI-2 Kunitz domain 1==
<StructureSection load='4u32' size='340' side='right' caption='[[4u32]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
<StructureSection load='4u32' size='340' side='right'caption='[[4u32]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4u32]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U32 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U32 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4u32]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U32 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4U32 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4u30|4u30]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4u32 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u32 OCA], [https://pdbe.org/4u32 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4u32 RCSB], [https://www.ebi.ac.uk/pdbsum/4u32 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4u32 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u32 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u32 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4u32 RCSB], [http://www.ebi.ac.uk/pdbsum/4u32 PDBsum]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/SPIT2_HUMAN SPIT2_HUMAN]] Congenital sodium diarrhea. The disease is caused by mutations affecting the gene represented in this entry.  
[https://www.uniprot.org/uniprot/SPIT2_HUMAN SPIT2_HUMAN] Congenital sodium diarrhea. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SPIT2_HUMAN SPIT2_HUMAN]] Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa. [[http://www.uniprot.org/uniprot/TRY3_HUMAN TRY3_HUMAN]] Digestive protease specialized for the degradation of trypsin inhibitors. In the ileum, may be involved in defensin processing, including DEFA5.<ref>PMID:12021776</ref> <ref>PMID:14507909</ref> 
[https://www.uniprot.org/uniprot/SPIT2_HUMAN SPIT2_HUMAN] Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4u32" style="background-color:#fffaf0;"></div>
==See Also==
*[[Hepatocyte growth factor activator inhibitor|Hepatocyte growth factor activator inhibitor]]
*[[Trypsin 3D structures|Trypsin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Trypsin]]
[[Category: Homo sapiens]]
[[Category: Radisky, E S]]
[[Category: Large Structures]]
[[Category: Soares, A S]]
[[Category: Radisky ES]]
[[Category: Wang, R]]
[[Category: Soares AS]]
[[Category: Enzyme kinetic]]
[[Category: Wang R]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Protease inhibitor]]
[[Category: Protein degradation]]
[[Category: Protein-protein interaction]]
[[Category: Proteolysis]]
[[Category: Serine protease]]
[[Category: Substrate specificity]]
Retrieved from "https://proteopedia.org/4u32"