5fiv: Difference between revisions

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<StructureSection load='5fiv' size='340' side='right'caption='[[5fiv]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='5fiv' size='340' side='right'caption='[[5fiv]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5fiv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Fiv Fiv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FIV OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5FIV FirstGlance]. <br>
<table><tr><td colspan='2'>[[5fiv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Feline_immunodeficiency_virus_(isolate_Petaluma) Feline immunodeficiency virus (isolate Petaluma)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FIV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FIV FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3TL:BENZYL+[(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-DIBENZYL-8,9-DIHYDROXY-1,16-DIMETHYL-4,13-BIS(1-METHYLETHYL)-2,5,12,15,18-PENTAOXO-20-PHENYL-19-OXA-3,6,11,14,17-PENTAAZAICOS-1-YL]CARBAMATE'>3TL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3TL:BENZYL+[(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-DIBENZYL-8,9-DIHYDROXY-1,16-DIMETHYL-4,13-BIS(1-METHYLETHYL)-2,5,12,15,18-PENTAOXO-20-PHENYL-19-OXA-3,6,11,14,17-PENTAAZAICOS-1-YL]CARBAMATE'>3TL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5fiv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fiv OCA], [http://pdbe.org/5fiv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fiv RCSB], [http://www.ebi.ac.uk/pdbsum/5fiv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fiv ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fiv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fiv OCA], [https://pdbe.org/5fiv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fiv RCSB], [https://www.ebi.ac.uk/pdbsum/5fiv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fiv ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/POL_FIVPE POL_FIVPE]] During replicative cycle of retroviruses, the reverse-transcribed viral DNA is integrated into the host chromosome by the viral integrase enzyme. RNase H activity is associated with the reverse transcriptase.  
[https://www.uniprot.org/uniprot/POL_FIVPE POL_FIVPE] During replicative cycle of retroviruses, the reverse-transcribed viral DNA is integrated into the host chromosome by the viral integrase enzyme. RNase H activity is associated with the reverse transcriptase.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Fiv]]
[[Category: HIV-1 retropepsin]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Elder, J]]
[[Category: Elder J]]
[[Category: Gustchina, A]]
[[Category: Gustchina A]]
[[Category: Laco, G]]
[[Category: Laco G]]
[[Category: Lee, T]]
[[Category: Lee T]]
[[Category: Li, M]]
[[Category: Li M]]
[[Category: Morris, G]]
[[Category: Morris G]]
[[Category: Olson, A]]
[[Category: Olson A]]
[[Category: Wlodawer, A]]
[[Category: Wlodawer A]]
[[Category: Wong, C]]
[[Category: Wong C]]
[[Category: Fiv protease]]
[[Category: Hydrolase-hydrolase inhibitor complex]]