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<StructureSection load='4uhl' size='340' side='right'caption='[[4uhl]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='4uhl' size='340' side='right'caption='[[4uhl]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4uhl]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UHL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UHL FirstGlance]. <br>
<table><tr><td colspan='2'>[[4uhl]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UHL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UHL FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=VFV:N-[(1R)-1-(3,4-DIFLUOROBIPHENYL-4-YL)-2-(1H-IMIDAZOL-1-YL)ETHYL]-4-(5-PHENYL-1,3,4-OXADIAZOL-2-YL)BENZAMIDE'>VFV</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4uhi|4uhi]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=VFV:N-[(1R)-1-(3,4-DIFLUOROBIPHENYL-4-YL)-2-(1H-IMIDAZOL-1-YL)ETHYL]-4-(5-PHENYL-1,3,4-OXADIAZOL-2-YL)BENZAMIDE'>VFV</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sterol_14-demethylase Sterol 14-demethylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.70 1.14.13.70] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uhl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uhl OCA], [https://pdbe.org/4uhl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uhl RCSB], [https://www.ebi.ac.uk/pdbsum/4uhl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uhl ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uhl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uhl OCA], [http://pdbe.org/4uhl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uhl RCSB], [http://www.ebi.ac.uk/pdbsum/4uhl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4uhl ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CP51A_HUMAN CP51A_HUMAN]] Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.  
[https://www.uniprot.org/uniprot/CP51A_HUMAN CP51A_HUMAN] Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4uhl" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4uhl" style="background-color:#fffaf0;"></div>
==See Also==
*[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Sterol 14-demethylase]]
[[Category: Hargrove TY]]
[[Category: Hargrove, T Y]]
[[Category: I Lepesheva G]]
[[Category: Lepesheva, G I]]
[[Category: Wawrzak Z]]
[[Category: Wawrzak, Z]]
[[Category: Cyp51]]
[[Category: Cytochrome p450]]
[[Category: Cytochrome p450 fold]]
[[Category: Endoplasmic reticulum]]
[[Category: Eukaryotic membrane]]
[[Category: Monooxygenase]]
[[Category: Oxidoreductase]]
[[Category: Sterol biosynthesis]]
Retrieved from "https://proteopedia.org/4uhl"