4unk: Difference between revisions
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==Crystal structure of human triosephosphate isomerase (mutant N15D)== | |||
<StructureSection load='4unk' size='340' side='right'caption='[[4unk]], [[Resolution|resolution]] 2.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4unk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UNK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UNK FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4unk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4unk OCA], [https://pdbe.org/4unk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4unk RCSB], [https://www.ebi.ac.uk/pdbsum/4unk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4unk ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/TPIS_HUMAN TPIS_HUMAN] Defects in TPI1 are the cause of triosephosphate isomerase deficiency (TPI deficiency) [MIM:[https://omim.org/entry/190450 190450]. TPI deficiency is an autosomal recessive disorder. It is the most severe clinical disorder of glycolysis. It is associated with neonatal jaundice, chronic hemolytic anemia, progressive neuromuscular dysfunction, cardiomyopathy and increased susceptibility to infection. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/TPIS_HUMAN TPIS_HUMAN] | |||
==See Also== | |||
*[[Triose phosphate isomerase 3D structures|Triose phosphate isomerase 3D structures]] | |||
__TOC__ | |||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Castillo-Villanueva A]] | ||
[[Category: | [[Category: DeLaMora-DeLaMora I]] | ||
[[Category: | [[Category: Enriquez-Flores S]] | ||
[[Category: | [[Category: Garcia-Torres I]] | ||
[[Category: | [[Category: Gomez-Manzo S]] | ||
[[Category: | [[Category: Lopez-Velazquez G]] | ||
[[Category: | [[Category: Marcial-Quino J]] | ||
[[Category: | [[Category: Mendez ST]] | ||
[[Category: | [[Category: Oria-Hernandez J]] | ||
[[Category: Torres- | [[Category: Reyes-Vivas H]] | ||
[[Category: Torres-Arroyo A]] | |||
[[Category: Torres-Larios A]] | |||
Latest revision as of 10:31, 10 January 2024
Crystal structure of human triosephosphate isomerase (mutant N15D)
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