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==Mtb TMK in complex with compound 8==
==Mtb TMK in complex with compound 8==
<StructureSection load='4unn' size='340' side='right' caption='[[4unn]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='4unn' size='340' side='right'caption='[[4unn]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4unn]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UNN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UNN FirstGlance]. <br>
<table><tr><td colspan='2'>[[4unn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UNN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UNN FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=QZZ:4-[3-CYANO-6-(3-METHOXYPHENYL)-2-OXO-1H-PYRIDIN-4-YL]BENZOIC+ACID'>QZZ</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dTMP_kinase dTMP kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.9 2.7.4.9] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=QZZ:4-[3-CYANO-6-(3-METHOXYPHENYL)-2-OXO-1H-PYRIDIN-4-YL]BENZOIC+ACID'>QZZ</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4unn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4unn OCA], [http://pdbe.org/4unn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4unn RCSB], [http://www.ebi.ac.uk/pdbsum/4unn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4unn ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4unn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4unn OCA], [https://pdbe.org/4unn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4unn RCSB], [https://www.ebi.ac.uk/pdbsum/4unn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4unn ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KTHY_MYCTU KTHY_MYCTU] Catalyzes the reversible phosphorylation of deoxythymidine monophosphate (dTMP) to deoxythymidine diphosphate (dTDP), using ATP as its preferred phosphoryl donor. Situated at the junction of both de novo and salvage pathways of deoxythymidine triphosphate (dTTP) synthesis, is essential for DNA synthesis and cellular growth. Has a broad specificity for nucleoside triphosphates, being highly active with ATP or dATP as phosphate donors, and less active with ITP, GTP, CTP and UTP.[HAMAP-Rule:MF_00165]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Thymidylate kinase|Thymidylate kinase]]
*[[Thymidylate kinase 3D structures|Thymidylate kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: DTMP kinase]]
[[Category: Large Structures]]
[[Category: Gingell, H]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Hussein, S]]
[[Category: Gingell H]]
[[Category: Read, J A]]
[[Category: Hussein S]]
[[Category: Tucker, J]]
[[Category: Read JA]]
[[Category: Atp tmp phosphotransferase]]
[[Category: Tucker J]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/4unn"