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==thermostabilised beta1-adrenoceptor with rationally designed inverse agonist 7-methylcyanopindolol bound==
==thermostabilised beta1-adrenoceptor with rationally designed inverse agonist 7-methylcyanopindolol bound==
<StructureSection load='5a8e' size='340' side='right' caption='[[5a8e]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='5a8e' size='340' side='right'caption='[[5a8e]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5a8e]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A8E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A8E FirstGlance]. <br>
<table><tr><td colspan='2'>[[5a8e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Meleagris_gallopavo Meleagris gallopavo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A8E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A8E FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MHA:(CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC+ACID'>MHA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=XTK:4-[(2S)-3-(TERT-BUTYLAMINO)-2-HYDROXYPROPOXY]-7-METHYL-1H-INDOLE-2-CARBONITRILE'>XTK</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a8e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a8e OCA], [http://pdbe.org/5a8e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a8e RCSB], [http://www.ebi.ac.uk/pdbsum/5a8e PDBsum]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MHA:(CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC+ACID'>MHA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=XTK:4-[(2S)-3-(TERT-BUTYLAMINO)-2-HYDROXYPROPOXY]-7-METHYL-1H-INDOLE-2-CARBONITRILE'>XTK</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a8e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a8e OCA], [https://pdbe.org/5a8e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a8e RCSB], [https://www.ebi.ac.uk/pdbsum/5a8e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a8e ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ADRB1_MELGA ADRB1_MELGA]] Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity.  
[https://www.uniprot.org/uniprot/ADRB1_MELGA ADRB1_MELGA] Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5a8e" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5a8e" style="background-color:#fffaf0;"></div>
==See Also==
*[[Adrenergic receptor 3D structures|Adrenergic receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Baker, J G]]
[[Category: Large Structures]]
[[Category: Brown, G A]]
[[Category: Meleagris gallopavo]]
[[Category: Congreve, M]]
[[Category: Baker JG]]
[[Category: Leslie, A G.W]]
[[Category: Brown GA]]
[[Category: Sato, T]]
[[Category: Congreve M]]
[[Category: Tate, C G]]
[[Category: Leslie AGW]]
[[Category: Warne, T]]
[[Category: Sato T]]
[[Category: Inverse agonist]]
[[Category: Tate CG]]
[[Category: Signaling protein]]
[[Category: Warne T]]
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