2bfi: Difference between revisions

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{{Seed}}
[[Image:2bfi.png|left|200px]]


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==Molecular basis for amyloid fibril formation and stability==
The line below this paragraph, containing "STRUCTURE_2bfi", creates the "Structure Box" on the page.
<StructureSection load='2bfi' size='340' side='right'caption='[[2bfi]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2bfi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BFI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BFI FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bfi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bfi OCA], [https://pdbe.org/2bfi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bfi RCSB], [https://www.ebi.ac.uk/pdbsum/2bfi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bfi ProSAT]</span></td></tr>
{{STRUCTURE_2bfi|  PDB=2bfi  |  SCENE=  }}
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The molecular structure of the amyloid fibril has remained elusive because of the difficulty of growing well diffracting crystals. By using a sequence-designed polypeptide, we have produced crystals of an amyloid fiber. These crystals diffract to high resolution (1 A) by electron and x-ray diffraction, enabling us to determine a detailed structure for amyloid. The structure reveals that the polypeptides form fibrous crystals composed of antiparallel beta-sheets in a cross-beta arrangement, characteristic of all amyloid fibers, and allows us to determine the side-chain packing within an amyloid fiber. The antiparallel beta-sheets are zipped together by means of pi-bonding between adjacent phenylalanine rings and salt-bridges between charge pairs (glutamic acid-lysine), thus controlling and stabilizing the structure. These interactions are likely to be important in the formation and stability of other amyloid fibrils.


===MOLECULAR BASIS FOR AMYLOID FIBRIL FORMATION AND STABILITY===
Molecular basis for amyloid fibril formation and stability.,Makin OS, Atkins E, Sikorski P, Johansson J, Serpell LC Proc Natl Acad Sci U S A. 2005 Jan 11;102(2):315-20. Epub 2005 Jan 3. PMID:15630094<ref>PMID:15630094</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The line below this paragraph, {{ABSTRACT_PUBMED_15630094}}, adds the Publication Abstract to the page
<div class="pdbe-citations 2bfi" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 15630094 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_15630094}}
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</StructureSection>
==About this Structure==
[[Category: Large Structures]]
2BFI is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BFI OCA].
[[Category: Synthetic construct]]
 
[[Category: Atkins E]]
==Reference==
[[Category: Johansson J]]
Molecular basis for amyloid fibril formation and stability., Makin OS, Atkins E, Sikorski P, Johansson J, Serpell LC, Proc Natl Acad Sci U S A. 2005 Jan 11;102(2):315-20. Epub 2005 Jan 3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15630094 15630094]
[[Category: Makin OS]]
[[Category: Single protein]]
[[Category: Serpell LC]]
[[Category: Atkins, E.]]
[[Category: Sikorski P]]
[[Category: Johansson, J.]]
[[Category: Makin, O Sumner.]]
[[Category: Serpell, L C.]]
[[Category: Sikorski, P.]]
[[Category: Amyloid]]
[[Category: Beta-sheet interaction]]
[[Category: Electron diffraction]]
[[Category: Fiber diffraction]]
[[Category: Pi-pi bonding]]
[[Category: X-ray diffraction]]
 
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