6tm1: Difference between revisions

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<StructureSection load='6tm1' size='340' side='right'caption='[[6tm1]], [[Resolution|resolution]] 3.71&Aring;' scene=''>
<StructureSection load='6tm1' size='340' side='right'caption='[[6tm1]], [[Resolution|resolution]] 3.71&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6tm1]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TM1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6TM1 FirstGlance]. <br>
<table><tr><td colspan='2'>[[6tm1]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TM1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TM1 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6tm1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tm1 OCA], [http://pdbe.org/6tm1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tm1 RCSB], [http://www.ebi.ac.uk/pdbsum/6tm1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tm1 ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.71&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tm1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tm1 OCA], [https://pdbe.org/6tm1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tm1 RCSB], [https://www.ebi.ac.uk/pdbsum/6tm1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tm1 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/DOC10_HUMAN DOC10_HUMAN]] Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression.[UniProtKB:Q8BZN6] [[http://www.uniprot.org/uniprot/RAC3_HUMAN RAC3_HUMAN]] Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles.<ref>PMID:11956649</ref>
[https://www.uniprot.org/uniprot/RAC3_HUMAN RAC3_HUMAN] Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles.<ref>PMID:11956649</ref>  
 
==See Also==
*[[Dedicator of cytokinesis protein 3D structures|Dedicator of cytokinesis protein 3D structures]]
*[[Rac 3D structures|Rac 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Barford, D]]
[[Category: Barford D]]
[[Category: Cronin, N]]
[[Category: Cronin N]]
[[Category: Fan, D]]
[[Category: Fan D]]
[[Category: Yang, J]]
[[Category: Yang J]]
[[Category: Dock10 gef rac3 gtpase]]
[[Category: Signaling protein]]

Latest revision as of 13:05, 24 January 2024

Crystal structure of the DHR2 domain of DOCK10 in complex with RAC3

6tm1, resolution 3.71Å

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