1a3c: Difference between revisions

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{{Seed}}
[[Image:1a3c.png|left|200px]]


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==PYRR, THE BACILLUS SUBTILIS PYRIMIDINE BIOSYNTHETIC OPERON REPRESSOR, DIMERIC FORM==
The line below this paragraph, containing "STRUCTURE_1a3c", creates the "Structure Box" on the page.
<StructureSection load='1a3c' size='340' side='right'caption='[[1a3c]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1a3c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A3C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A3C FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SM:SAMARIUM+(III)+ION'>SM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_1a3c|  PDB=1a3c  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a3c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a3c OCA], [https://pdbe.org/1a3c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a3c RCSB], [https://www.ebi.ac.uk/pdbsum/1a3c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a3c ProSAT]</span></td></tr>
 
</table>
===PYRR, THE BACILLUS SUBTILIS PYRIMIDINE BIOSYNTHETIC OPERON REPRESSOR, DIMERIC FORM===
== Function ==
 
[https://www.uniprot.org/uniprot/PYRR_BACSU PYRR_BACSU] Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes.[HAMAP-Rule:MF_01219]  Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.[HAMAP-Rule:MF_01219]
 
== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a3/1a3c_consurf.spt"</scriptWhenChecked>
{{ABSTRACT_PUBMED_9551555}}
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    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
1A3C is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A3C OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a3c ConSurf].
 
<div style="clear:both"></div>
==Reference==
__TOC__
Adaptation of an enzyme to regulatory function: structure of Bacillus subtilis PyrR, a pyr RNA-binding attenuation protein and uracil phosphoribosyltransferase., Tomchick DR, Turner RJ, Switzer RL, Smith JL, Structure. 1998 Mar 15;6(3):337-50. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9551555 9551555]
</StructureSection>
[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Smith, J L.]]
[[Category: Smith JL]]
[[Category: Switzer, R W.]]
[[Category: Switzer RW]]
[[Category: Tomchick, D R.]]
[[Category: Tomchick DR]]
[[Category: Turner, R J.]]
[[Category: Turner RJ]]
[[Category: Attenuation protein]]
[[Category: Bifunctional enzyme]]
[[Category: Phosphoribosyltransferase]]
[[Category: Prtase]]
[[Category: Pyrimidine biosynthesis]]
[[Category: Rna-binding protein]]
[[Category: Transcription regulation]]
[[Category: Transferase]]
 
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Retrieved from "https://proteopedia.org/1a3c"